Subclinical left ventricular dysfunction in multiple sclerosis

Ferit Akgül, Ismet Mclek, Taşkin Duman, Ergün Seyfelì, Tunzale Seydaliyeva, Fatih Yalçin

Research output: Contribution to journalArticlepeer-review


Objectives - To investigate the left (LV) and right ventricular (RV) function in multiple sclerosis (MS) using standard echocardiography and Doppler tissue imaging (DTI). Materials and methods - A total of 41 patients with definite MS and 32 healthy controls were included in the study. Results - LV end-systolic dimension was increased and LV ejection fraction was decreased in MS patients compared with controls (P <0.05). LV end-diastolic dimension was increased in MS patients, however, did not reach significance. Among DTI parameters, mitral annular peak early diastolic velocity to peak late diastolic velocity ratio (Em/Am) was decreased in MS patients, but not reach statistical significance. No significant differences in tricuspid annular Em/Am ratio was found between MS patients and controls. A statistically significant increase of DTI derived LV myocardial performance index was found in MS patients as compared with controls. RV myocardial performance index showed a tendency to be increased in MS patients, however, did not reach significance. Conclusions - These findings suggest subclinical LV dysfunction and preserved RV function in patients with MS.

Original languageEnglish (US)
Pages (from-to)114-118
Number of pages5
JournalActa Neurologica Scandinavica
Issue number2
StatePublished - Aug 2006
Externally publishedYes


  • Multiple sclerosis
  • Tissue doppler
  • Ventricular function

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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