Subclinical coronary and aortic atherosclerosis detected by magnetic resonance imaging in type 1 diabetes with and without diabetic nephropathy

Won Yong Kim, Anne Sofie Astrup, Matthias Stuber, Lise Tarnow, Erling Falk, René M. Botnar, Cheryl Simonsen, Lotte Pietraszek, Peter R. Hansen, Warren J. Manning, Niels T. Andersen, Hans Henrik Parving

Research output: Contribution to journalArticle

Abstract

BACKGROUND - Patients with type 1 diabetes and nephropathy maintain an excess cardiovascular mortality compared with diabetic patients with normoalbuminuria. We sought to evaluate coronary and aortic atherosclerosis in a cohort of asymptomatic type 1 diabetic patients with and without diabetic nephropathy using cardiovascular magnetic resonance imaging. METHODS AND RESULTS - In a cross-sectional study, 136 subjects with long-standing type 1 diabetes without symptoms or history of cardiovascular disease, including 63 patients (46%) with nephropathy and 73 patients with normoalbuminuria, underwent cardiovascular magnetic resonance imaging. All subjects underwent cardiac exercise testing and noninvasive tests for peripheral artery disease and autonomic neuropathy. Coronary artery stenoses were identified in 10% of subjects with nephropathy (versus 0% with normoalbuminuria; P=0.007). Coronary plaque burden, expressed as right coronary artery mean wall thickness (1.7±0.3 versus 1.3±0.2 mm; P

Original languageEnglish (US)
Pages (from-to)228-235
Number of pages8
JournalCirculation
Volume115
Issue number2
DOIs
StatePublished - Jan 2007
Externally publishedYes

Fingerprint

Diabetic Nephropathies
Type 1 Diabetes Mellitus
Coronary Artery Disease
Magnetic Resonance Imaging
Coronary Stenosis
Peripheral Arterial Disease
Coronary Vessels
Cardiovascular Diseases
Cross-Sectional Studies
Exercise
Mortality

Keywords

  • Aorta
  • Atherosclerosis
  • Coronary disease
  • Diabetes mellitus
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Subclinical coronary and aortic atherosclerosis detected by magnetic resonance imaging in type 1 diabetes with and without diabetic nephropathy. / Kim, Won Yong; Astrup, Anne Sofie; Stuber, Matthias; Tarnow, Lise; Falk, Erling; Botnar, René M.; Simonsen, Cheryl; Pietraszek, Lotte; Hansen, Peter R.; Manning, Warren J.; Andersen, Niels T.; Parving, Hans Henrik.

In: Circulation, Vol. 115, No. 2, 01.2007, p. 228-235.

Research output: Contribution to journalArticle

Kim, WY, Astrup, AS, Stuber, M, Tarnow, L, Falk, E, Botnar, RM, Simonsen, C, Pietraszek, L, Hansen, PR, Manning, WJ, Andersen, NT & Parving, HH 2007, 'Subclinical coronary and aortic atherosclerosis detected by magnetic resonance imaging in type 1 diabetes with and without diabetic nephropathy', Circulation, vol. 115, no. 2, pp. 228-235. https://doi.org/10.1161/CIRCULATIONAHA.106.633339
Kim, Won Yong ; Astrup, Anne Sofie ; Stuber, Matthias ; Tarnow, Lise ; Falk, Erling ; Botnar, René M. ; Simonsen, Cheryl ; Pietraszek, Lotte ; Hansen, Peter R. ; Manning, Warren J. ; Andersen, Niels T. ; Parving, Hans Henrik. / Subclinical coronary and aortic atherosclerosis detected by magnetic resonance imaging in type 1 diabetes with and without diabetic nephropathy. In: Circulation. 2007 ; Vol. 115, No. 2. pp. 228-235.
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