Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: The multiethnic study of atherosclerosis

Ronald Klein, Barbara E.K. Klein, Michael D. Knudtson, Mary Frances Cotch, Yin Wong Tien, Kiang Liu, Gregory L. Burke, Mohammed F. Saad, David R. Jacobs, A. Richey Sharrett

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Abstract

Objective: To investigate the relationship of subclinical atherosclerotic cardiovascular disease (CVD) and its risk factors with age-related macular degeneration (AMD) in the Multiethnic Study of Atherosclerosis. Methods: This study included 6176 white, black, Hispanic, and Chinese participants aged 44 to 84 years from 6 communities in the United States. Measurements of subclinical CVD were performed according to standardized protocols. Fundus images were graded using the Wisconsin Age-Related Maculopathy Grading System. Results: In analyses controlled for age, sex, race/ethnicity, and study location, early AMD was associated with a higher serum high-density lipoprotein cholesterol level (odds ratio per 15 mg/dL, 1.16; 95% confidence interval, 1.01-1.36) and the presence of echolucent carotid artery plaque (odds ratio for present vs no plaque, 0.37; 95% confidence interval, 0.18-0.74) in the whole cohort. Interactions of race/ethnicity and early AMD were found for carotid intima-media thickness, increasing severity of maximum carotid artery stenosis, serum triglyceride level, subclinical CVD severity, and Agatston calcium score. Conclusion: Few associations were found between subclinical CVD and CVD risk factors with early AMD. The findings of associations of early AMD with some signs of subclinical atherosclerotic CVD are different among the 4 racial/ethnic groups, which suggests that care must be taken in generalizing from one racial/ethnic group to another.

Original languageEnglish (US)
Pages (from-to)534-543
Number of pages10
JournalArchives of ophthalmology
Volume125
Issue number4
DOIs
StatePublished - Apr 1 2007

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ASJC Scopus subject areas

  • Ophthalmology

Cite this

Klein, R., Klein, B. E. K., Knudtson, M. D., Cotch, M. F., Tien, Y. W., Liu, K., Burke, G. L., Saad, M. F., Jacobs, D. R., & Sharrett, A. R. (2007). Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: The multiethnic study of atherosclerosis. Archives of ophthalmology, 125(4), 534-543. https://doi.org/10.1001/archopht.125.4.534