Subclinical acute antibody-mediated rejection in positive crossmatch renal allografts

M. Haas, R. A. Montgomery, D. L. Segev, M. H. Rahman, L. C. Racusen, S. M. Bagnasco, C. E. Simpkins, D. S. Warren, D. Lepley, A. A. Zachary, E. S. Kraus

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


Subclinical antibody-mediated rejection (AMR) has been described in renal allograft recipients with stable serum creatinine (SCr), however whether this leads to development of chronic allograft nephropathy (CAN) remains unknown. We retrospectively reviewed data from 83 patients who received HLA-incompatible renal allografts following desensitization to remove donor-specific antibodies (DSA). Ten patients had an allograft biopsy showing subclinical AMR [stable SCr, neutrophil margination in peritubular capillaries (PTC), diffuse PTC C4d, positive DSA] during the first year post-transplantation; 3 patients were treated with plasmapheresis and intravenous immunoglobulin. Three patients had a subsequent rise in SCr and an associated biopsy with AMR; 5 others showed diagnostic or possible subclinical AMR on a later protocol biopsy. One graft was lost, while remaining patients have normal or mildly elevated SCr 8-45 months post-transplantation. However, the mean increase in CAN score (cg + ci + ct + cv) from those biopsies showing subclinical AMR to follow-up biopsies 335 ± 248 (SD) days later was significantly greater (3.5 ± 2.5 versus 1.0 ± 2.0, p = 0.01) than that in 24 recipients of HLA-incompatible grafts with no AMR over a similar interval (360 ± 117 days), suggesting that subclinical AMR may contribute to development of CAN.

Original languageEnglish (US)
Pages (from-to)576-585
Number of pages10
JournalAmerican Journal of Transplantation
Issue number3
StatePublished - Mar 2007


  • Accomodation
  • C4d
  • Chronic rejection
  • Protocol biopsy
  • Renal transplantation
  • Transplant glomerulopathy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)


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