Subclassifcation of microsatellite-unstable tumors in colorectal cancer

Research output: Contribution to journalReview articlepeer-review

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is an inherited syndrome with a germline mutation in the mismatch repair (MMR) genes. Microsatellite instability is found in most of these tumors, but it also appears in 15% to 20% of all sporadic colorectal cancers. Although the phenotype in both these cancers is the same, the genotype is different. In HNPCC tumors, MMR errors are due to an inherited mutation in the MMR gene, K-ras mutation is frequent, and most arise from villous adenomas. In sporadic colorectal cancers, MMR errors are due to epigenetic silencing of the MMR gene MLH1, the BRAF-V600E mutation is frequent, and most arise from the serrated-polyp pathway. This article reviews the genetic, clinical, and pathologic differences and similarities between these tumor types.

Original languageEnglish (US)
Pages (from-to)212-219
Number of pages8
JournalCurrent Colorectal Cancer Reports
Volume3
Issue number4
DOIs
StatePublished - Oct 1 2007

ASJC Scopus subject areas

  • Hepatology
  • Oncology
  • Gastroenterology

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