Subcellular optical coherence tomography with a Kerr lens mode-locked Ti

Al2O3 laser

Wolfgang Drexler, Uwe Morgner, Costas Pitris, Stephen A. Boppart, Franz X. Kartner, Xingde Li, Seong Ho Cho, Erich P. Ippen, Mark E. Brezinski, James G. Fujimoto

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The longitudinal resolution of optical coherence tomography (OCT) is currently limited by the optical bandwidth of the light source, typically a superluminescent diodes, to approximately 10-15 μm. This resolution is insufficient to identify individual cells or to assess subcellular structures such as nuclei or mitotic figures. The ability to perform subcellular imaging with OCT could greatly enhance the detection of early neoplastic changes and improve early cancer diagnosis or the imaging of developing biological morphology. Higher resolution OCT would also improve specificity of diagnosis for several ocular diseases, such as glaucoma, which require precise, detailed imaging and measurement of retinal nerve fiber layer thickness. State of the art Kerr-lens mode-locked (KLM) Ti:A2O3 lasers using double chirped dispersion compensating mirrors can generate pulse durations of 2O3 laser. In vivo imaging of developmental biology specimens as well as preliminary in vivo spectroscopic OCT results are demonstrated.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages216-223
Number of pages8
Volume3598
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III - San Jose, CA, USA
Duration: Jan 27 1999Jan 29 1999

Other

OtherProceedings of the 1999 Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III
CitySan Jose, CA, USA
Period1/27/991/29/99

Fingerprint

Optical tomography
Laser modes
Lenses
tomography
lenses
Imaging techniques
Lasers
lasers
glaucoma
nerve fibers
biology
Light sources
Laser pulses
light sources
pulse duration
Diodes
cancer
diodes
mirrors
bandwidth

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Drexler, W., Morgner, U., Pitris, C., Boppart, S. A., Kartner, F. X., Li, X., ... Fujimoto, J. G. (1999). Subcellular optical coherence tomography with a Kerr lens mode-locked Ti: Al2O3 laser. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3598, pp. 216-223). Society of Photo-Optical Instrumentation Engineers.

Subcellular optical coherence tomography with a Kerr lens mode-locked Ti : Al2O3 laser. / Drexler, Wolfgang; Morgner, Uwe; Pitris, Costas; Boppart, Stephen A.; Kartner, Franz X.; Li, Xingde; Cho, Seong Ho; Ippen, Erich P.; Brezinski, Mark E.; Fujimoto, James G.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3598 Society of Photo-Optical Instrumentation Engineers, 1999. p. 216-223.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drexler, W, Morgner, U, Pitris, C, Boppart, SA, Kartner, FX, Li, X, Cho, SH, Ippen, EP, Brezinski, ME & Fujimoto, JG 1999, Subcellular optical coherence tomography with a Kerr lens mode-locked Ti: Al2O3 laser. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3598, Society of Photo-Optical Instrumentation Engineers, pp. 216-223, Proceedings of the 1999 Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III, San Jose, CA, USA, 1/27/99.
Drexler W, Morgner U, Pitris C, Boppart SA, Kartner FX, Li X et al. Subcellular optical coherence tomography with a Kerr lens mode-locked Ti: Al2O3 laser. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3598. Society of Photo-Optical Instrumentation Engineers. 1999. p. 216-223
Drexler, Wolfgang ; Morgner, Uwe ; Pitris, Costas ; Boppart, Stephen A. ; Kartner, Franz X. ; Li, Xingde ; Cho, Seong Ho ; Ippen, Erich P. ; Brezinski, Mark E. ; Fujimoto, James G. / Subcellular optical coherence tomography with a Kerr lens mode-locked Ti : Al2O3 laser. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3598 Society of Photo-Optical Instrumentation Engineers, 1999. pp. 216-223
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