We investigated the immunosuppression activity of the 'classical' calmodulin inhibitors, R24571, W-7 (a naphthalene sulfonamide) and trifluoroperazine (a phenothiazine), alone and in combination with CsA in the one-way mixed lymphocyte reaction (MLR). We also analyzed the effect of exogenous calmodulin on the MLR and CsA inhibition of the MLR. The one-way MLR provides a convenient in vitro model for the immune response following transplantation and is exquisitely sensitive to inhibition by CsA.
|Original language||English (US)|
|Number of pages||4|
|Issue number||1 II|
|State||Published - 1987|
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