Subcellular action of cyclosporine: Interaction between CsA and calmodulin antagonists

Paul Colombani, E. C. Bright, O. Monastyrskyj, A. D. Hess

Research output: Contribution to journalArticle

Abstract

We investigated the immunosuppression activity of the 'classical' calmodulin inhibitors, R24571, W-7 (a naphthalene sulfonamide) and trifluoroperazine (a phenothiazine), alone and in combination with CsA in the one-way mixed lymphocyte reaction (MLR). We also analyzed the effect of exogenous calmodulin on the MLR and CsA inhibition of the MLR. The one-way MLR provides a convenient in vitro model for the immune response following transplantation and is exquisitely sensitive to inhibition by CsA.

Original languageEnglish (US)
Pages (from-to)1171-1174
Number of pages4
JournalTransplantation Proceedings
Volume19
Issue number1 II
StatePublished - 1987

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Mixed Lymphocyte Culture Test
Calmodulin
Cyclosporine
calmidazolium
Trifluoperazine
Sulfonamides
Immunosuppression
Transplantation

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Subcellular action of cyclosporine : Interaction between CsA and calmodulin antagonists. / Colombani, Paul; Bright, E. C.; Monastyrskyj, O.; Hess, A. D.

In: Transplantation Proceedings, Vol. 19, No. 1 II, 1987, p. 1171-1174.

Research output: Contribution to journalArticle

Colombani, P, Bright, EC, Monastyrskyj, O & Hess, AD 1987, 'Subcellular action of cyclosporine: Interaction between CsA and calmodulin antagonists', Transplantation Proceedings, vol. 19, no. 1 II, pp. 1171-1174.
Colombani, Paul ; Bright, E. C. ; Monastyrskyj, O. ; Hess, A. D. / Subcellular action of cyclosporine : Interaction between CsA and calmodulin antagonists. In: Transplantation Proceedings. 1987 ; Vol. 19, No. 1 II. pp. 1171-1174.
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