Abstract
We investigated the immunosuppression activity of the 'classical' calmodulin inhibitors, R24571, W-7 (a naphthalene sulfonamide) and trifluoroperazine (a phenothiazine), alone and in combination with CsA in the one-way mixed lymphocyte reaction (MLR). We also analyzed the effect of exogenous calmodulin on the MLR and CsA inhibition of the MLR. The one-way MLR provides a convenient in vitro model for the immune response following transplantation and is exquisitely sensitive to inhibition by CsA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1171-1174 |
| Number of pages | 4 |
| Journal | Transplantation Proceedings |
| Volume | 19 |
| Issue number | 1 II |
| State | Published - 1987 |
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ASJC Scopus subject areas
- Surgery
- Transplantation
Cite this
Subcellular action of cyclosporine : Interaction between CsA and calmodulin antagonists. / Colombani, Paul; Bright, E. C.; Monastyrskyj, O.; Hess, A. D.
In: Transplantation Proceedings, Vol. 19, No. 1 II, 1987, p. 1171-1174.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subcellular action of cyclosporine
T2 - Interaction between CsA and calmodulin antagonists
AU - Colombani, Paul
AU - Bright, E. C.
AU - Monastyrskyj, O.
AU - Hess, A. D.
PY - 1987
Y1 - 1987
N2 - We investigated the immunosuppression activity of the 'classical' calmodulin inhibitors, R24571, W-7 (a naphthalene sulfonamide) and trifluoroperazine (a phenothiazine), alone and in combination with CsA in the one-way mixed lymphocyte reaction (MLR). We also analyzed the effect of exogenous calmodulin on the MLR and CsA inhibition of the MLR. The one-way MLR provides a convenient in vitro model for the immune response following transplantation and is exquisitely sensitive to inhibition by CsA.
AB - We investigated the immunosuppression activity of the 'classical' calmodulin inhibitors, R24571, W-7 (a naphthalene sulfonamide) and trifluoroperazine (a phenothiazine), alone and in combination with CsA in the one-way mixed lymphocyte reaction (MLR). We also analyzed the effect of exogenous calmodulin on the MLR and CsA inhibition of the MLR. The one-way MLR provides a convenient in vitro model for the immune response following transplantation and is exquisitely sensitive to inhibition by CsA.
UR - http://www.scopus.com/inward/record.url?scp=0023139664&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023139664&partnerID=8YFLogxK
M3 - Article
C2 - 2950628
AN - SCOPUS:0023139664
VL - 19
SP - 1171
EP - 1174
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 1 II
ER -