Subcellular action of cyclosporine: Interaction between CsA and calmodulin antagonists

P. M. Colombani; E. C. Bright; O. Monastyrskyj; A. D. Hess

Subcellular action of cyclosporine: Interaction between CsA and calmodulin antagonists

P. M. Colombani, E. C. Bright, O. Monastyrskyj, A. D. Hess

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the immunosuppression activity of the 'classical' calmodulin inhibitors, R24571, W-7 (a naphthalene sulfonamide) and trifluoroperazine (a phenothiazine), alone and in combination with CsA in the one-way mixed lymphocyte reaction (MLR). We also analyzed the effect of exogenous calmodulin on the MLR and CsA inhibition of the MLR. The one-way MLR provides a convenient in vitro model for the immune response following transplantation and is exquisitely sensitive to inhibition by CsA.

Original language	English (US)
Pages (from-to)	1171-1174
Number of pages	4
Journal	Transplantation proceedings
Volume	19
Issue number	1 II
State	Published - 1987

ASJC Scopus subject areas

Surgery
Transplantation

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year = "1987",

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AU - Monastyrskyj, O.

AU - Hess, A. D.

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