Subcellular action of cyclosporine: Interaction between CsA and calmodulin antagonists

P. M. Colombani, E. C. Bright, O. Monastyrskyj, A. D. Hess

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the immunosuppression activity of the 'classical' calmodulin inhibitors, R24571, W-7 (a naphthalene sulfonamide) and trifluoroperazine (a phenothiazine), alone and in combination with CsA in the one-way mixed lymphocyte reaction (MLR). We also analyzed the effect of exogenous calmodulin on the MLR and CsA inhibition of the MLR. The one-way MLR provides a convenient in vitro model for the immune response following transplantation and is exquisitely sensitive to inhibition by CsA.

Original languageEnglish (US)
Pages (from-to)1171-1174
Number of pages4
JournalTransplantation proceedings
Volume19
Issue number1 II
StatePublished - 1987

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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