Abstract
We investigated the immunosuppression activity of the 'classical' calmodulin inhibitors, R24571, W-7 (a naphthalene sulfonamide) and trifluoroperazine (a phenothiazine), alone and in combination with CsA in the one-way mixed lymphocyte reaction (MLR). We also analyzed the effect of exogenous calmodulin on the MLR and CsA inhibition of the MLR. The one-way MLR provides a convenient in vitro model for the immune response following transplantation and is exquisitely sensitive to inhibition by CsA.
Original language | English (US) |
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Pages (from-to) | 1171-1174 |
Number of pages | 4 |
Journal | Transplantation proceedings |
Volume | 19 |
Issue number | 1 II |
State | Published - 1987 |
ASJC Scopus subject areas
- Surgery
- Transplantation