Subarachnoid blood and headache: Altered trigeminal tachykinin gene expression

M. D. Linnik, D. E. Sakas, G. R. Uhl, M. A. Moskowitz

Research output: Contribution to journalArticle

Abstract

Sensory axons from the trigeminal ganglion (V) innervate cephalic blood vessels and use the preprotachykinin gene products, substance P (SP) and neurokinin A (NKA), as putative neurotransmitters conveying information. Blood in the subarachnoid space is accompanied by severe headache. We now report that this painful stimulus, which should enhance activity in V, specifically alters tachykinin peptide and mRNA levels in V and perivascular axons. Marked reductions in SP levels were observed in basilar artery segments within 4 hours after intracisternal blood injection which persisted for 48 hours and recovered by 7 days. SP peptide levels in V were elevated by 49% two days after blood injection. The changes in SP peptide levels were accompanied by increases in ganglionic content of the preprotachykinin mRNA that codes for the peptide. Blood-induced peptide depletion in arteries and subsequent increases in peptide and mRNA in V are consistent with increased neuronal activity and enhanced neuropeptide release. These results implicate the tachykinin-utilizing trigeminovascular neurons in the sequelae of subarachnoid hemorrhage.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalAnnals of Neurology
Volume25
Issue number2
StatePublished - 1989

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Tachykinins
Headache
Substance P
Gene Expression
Peptides
Messenger RNA
Axons
Neurokinin A
Trigeminal Ganglion
Subarachnoid Space
Injections
Basilar Artery
Subarachnoid Hemorrhage
Neuropeptides
Neurotransmitter Agents
Blood Vessels
Arteries
Head
Neurons
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Linnik, M. D., Sakas, D. E., Uhl, G. R., & Moskowitz, M. A. (1989). Subarachnoid blood and headache: Altered trigeminal tachykinin gene expression. Annals of Neurology, 25(2), 179-184.

Subarachnoid blood and headache : Altered trigeminal tachykinin gene expression. / Linnik, M. D.; Sakas, D. E.; Uhl, G. R.; Moskowitz, M. A.

In: Annals of Neurology, Vol. 25, No. 2, 1989, p. 179-184.

Research output: Contribution to journalArticle

Linnik, MD, Sakas, DE, Uhl, GR & Moskowitz, MA 1989, 'Subarachnoid blood and headache: Altered trigeminal tachykinin gene expression', Annals of Neurology, vol. 25, no. 2, pp. 179-184.
Linnik MD, Sakas DE, Uhl GR, Moskowitz MA. Subarachnoid blood and headache: Altered trigeminal tachykinin gene expression. Annals of Neurology. 1989;25(2):179-184.
Linnik, M. D. ; Sakas, D. E. ; Uhl, G. R. ; Moskowitz, M. A. / Subarachnoid blood and headache : Altered trigeminal tachykinin gene expression. In: Annals of Neurology. 1989 ; Vol. 25, No. 2. pp. 179-184.
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