Subacute stent thrombosis owing to complete clopidogrel resistance successfully managed with prasugrel

Michael P. Flaherty, Peter V. Johnston, Jeffrey J. Rade

Research output: Contribution to journalArticlepeer-review

Abstract

This report describes a case of an acute anterior myocardial infarction secondary to subacute stent thrombosis of a drug-eluting stent within the proximal segment of the left anterior descending artery (LAD) 5 days after percutaneous transluminal coronary angioplasty and stenting (PCI). The patient was initially managed with conventional dual-antiplatelet therapy (aspirin and clopidogrel) and was subsequently found to have complete absence of adenosine diphosphate (ADP) receptor P2Y12 receptor inhibition. Following additional PCI of the LAD and substitution of clopidogrel for the thienopyridine prasugrel, therapeutic platelet inhibition was achieved without recurrence of stent thrombosis.

Original languageEnglish (US)
Pages (from-to)300-304
Number of pages5
JournalJournal of Invasive Cardiology
Volume23
Issue number7
StatePublished - Jul 1 2011

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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