Sub-optimal vitamin B-12 levels among ART-naïve HIV-positive individuals in an urban cohort in uganda

Aggrey S. Semeere, Damalie Nakanjako, Henry Ddungu, Andrew Kambugu, Yukari C Manabe, Robert Colebunders

Research output: Contribution to journalArticle

Abstract

Malnutrition is common among HIV-infected individuals and is often accompanied by low serum levels of micronutrients. Vitamin B-12 deficiency has been associated with various factors including faster HIV disease progression and CD4 depletion in resource-rich settings. To describe prevalence and factors associated with sub-optimal vitamin B-12 levels among HIV-infected antiretroviral therapy (ART) naïve adults in a resource-poor setting, we performed a cross-sectional study with a retrospective chart review among individuals attending either the Mulago-Mbarara teaching hospitals' Joint AIDS Program (MJAP) or the Infectious Diseases Institute (IDI) clinics, in Kampala, Uganda. Logistic regression was used to determine factors associated with sub-optimal vitamin B-12. The mean vitamin B-12 level was 384 pg/ml, normal range (200-900). Sub-optimal vitamin B-12 levels (

Original languageEnglish (US)
Article numbere40072
JournalPLoS One
Volume7
Issue number7
DOIs
StatePublished - Jul 2 2012

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Uganda
vitamin B12
Vitamin B 12
HIV
therapeutics
Vitamin B 12 Deficiency
Micronutrients
Therapeutics
Teaching Hospitals
Malnutrition
Communicable Diseases
Disease Progression
Reference Values
Acquired Immunodeficiency Syndrome
disease course
cross-sectional studies
Cross-Sectional Studies
Joints
Logistic Models
malnutrition

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Sub-optimal vitamin B-12 levels among ART-naïve HIV-positive individuals in an urban cohort in uganda. / Semeere, Aggrey S.; Nakanjako, Damalie; Ddungu, Henry; Kambugu, Andrew; Manabe, Yukari C; Colebunders, Robert.

In: PLoS One, Vol. 7, No. 7, e40072, 02.07.2012.

Research output: Contribution to journalArticle

Semeere, Aggrey S. ; Nakanjako, Damalie ; Ddungu, Henry ; Kambugu, Andrew ; Manabe, Yukari C ; Colebunders, Robert. / Sub-optimal vitamin B-12 levels among ART-naïve HIV-positive individuals in an urban cohort in uganda. In: PLoS One. 2012 ; Vol. 7, No. 7.
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