Studying Myc's role in metabolism regulation

Anne Le, Chi V. Dang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The MYC oncogene encodes a master transcription factor, Myc, which regulates genes involved in ribosome biogenesis, lipid synthesis, nucleic acid synthesis, intermediary metabolism, and cell growth and proliferation. The genomics of Myc target genes has been well-established through global mapping of Myc binding sites in a variety of different cancer cell lines. These studies highlight the importance of Myc in regulating glucose and glutamine metabolism as well as mitochondrial and ribosomal biogenesis. These genomic studies, however, only become relevant with the companion metabolic studies using a variety of methods to measure oxygen consumption, glucose uptake, or metabolic pathways based on 13C-labeled glucose or glutamine uptake. These methods are described herein.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages213-219
Number of pages7
Volume1012
DOIs
StatePublished - 2013

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Glutamine
Glucose
myc Genes
Organelle Biogenesis
Genomics
Metabolic Networks and Pathways
Ribosomes
Oncogenes
Oxygen Consumption
Nucleic Acids
Transcription Factors
Binding Sites
Cell Proliferation
Lipids
Cell Line
Growth
Genes
Neoplasms

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Le, A., & Dang, C. V. (2013). Studying Myc's role in metabolism regulation. In Methods in Molecular Biology (Vol. 1012, pp. 213-219) https://doi.org/10.1007/978-1-62703-429-6-14

Studying Myc's role in metabolism regulation. / Le, Anne; Dang, Chi V.

Methods in Molecular Biology. Vol. 1012 2013. p. 213-219.

Research output: Chapter in Book/Report/Conference proceedingChapter

Le, A & Dang, CV 2013, Studying Myc's role in metabolism regulation. in Methods in Molecular Biology. vol. 1012, pp. 213-219. https://doi.org/10.1007/978-1-62703-429-6-14
Le A, Dang CV. Studying Myc's role in metabolism regulation. In Methods in Molecular Biology. Vol. 1012. 2013. p. 213-219 https://doi.org/10.1007/978-1-62703-429-6-14
Le, Anne ; Dang, Chi V. / Studying Myc's role in metabolism regulation. Methods in Molecular Biology. Vol. 1012 2013. pp. 213-219
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