TY - JOUR
T1 - Study protocol, sample characteristics, and loss to follow-up
T2 - The OPPERA prospective cohort study
AU - Bair, Eric
AU - Brownstein, Naomi C.
AU - Ohrbach, Richard
AU - Greenspan, Joel D.
AU - Dubner, Ronald
AU - Fillingim, Roger B.
AU - Maixner, William
AU - Smith, Shad B.
AU - Diatchenko, Luda
AU - Gonzalez, Yoly
AU - Gordon, Sharon M.
AU - Lim, Pei Feng
AU - Ribeiro-Dasilva, Margarete
AU - Dampier, Dawn
AU - Knott, Charles
AU - Slade, Gary D.
PY - 2013/12
Y1 - 2013/12
N2 - When studying incidence of pain conditions such as temporomandibular disorder (TMD), repeated monitoring is needed in prospective cohort studies. However, monitoring methods usually have limitations and, over a period of years, some loss to follow-up is inevitable. TheOPPERAprospective cohort study of first-onset TMD screened for symptoms using quarterly questionnaires and examined symptomatic participants to definitively ascertain TMD incidence. During the median 2.8-year observation period, 16%of the 3,263 enrollees completed no follow-up questionnaires, others provided incomplete follow-up, and examinationswere not conducted for one third of symptomatic episodes. Although screeningmethods and examinationswere found to have excellent reliability and validity, theywere not perfect. Loss to follow-up varied according to some putative TMD risk factors, although multiple imputation to correct the problemsuggested that biaswas minimal. A secondmethod of multiple imputation that evaluated bias associated with omitted and dubious examinations revealed a slight underestimate of incidence and somesmall biases in hazard ratios used toquantify effects of risk factors. Although''bottom line'' statistical conclusions were not affected, multiply-imputed estimates should be considered when evaluating the large number of risk factors under investigation in the OPPERA study. Perspective: These findings support the validity of the OPPERA prospective cohort study for the purpose of investigating the etiology of first-onset TMD, providing the foundation for other papers investigating risk factors hypothesized in the OPPERA project.
AB - When studying incidence of pain conditions such as temporomandibular disorder (TMD), repeated monitoring is needed in prospective cohort studies. However, monitoring methods usually have limitations and, over a period of years, some loss to follow-up is inevitable. TheOPPERAprospective cohort study of first-onset TMD screened for symptoms using quarterly questionnaires and examined symptomatic participants to definitively ascertain TMD incidence. During the median 2.8-year observation period, 16%of the 3,263 enrollees completed no follow-up questionnaires, others provided incomplete follow-up, and examinationswere not conducted for one third of symptomatic episodes. Although screeningmethods and examinationswere found to have excellent reliability and validity, theywere not perfect. Loss to follow-up varied according to some putative TMD risk factors, although multiple imputation to correct the problemsuggested that biaswas minimal. A secondmethod of multiple imputation that evaluated bias associated with omitted and dubious examinations revealed a slight underestimate of incidence and somesmall biases in hazard ratios used toquantify effects of risk factors. Although''bottom line'' statistical conclusions were not affected, multiply-imputed estimates should be considered when evaluating the large number of risk factors under investigation in the OPPERA study. Perspective: These findings support the validity of the OPPERA prospective cohort study for the purpose of investigating the etiology of first-onset TMD, providing the foundation for other papers investigating risk factors hypothesized in the OPPERA project.
KW - Cohort studies
KW - Epidemiologic methods
KW - Population statistics
KW - Proportional hazards models
KW - Temporomandibular disorder
UR - http://www.scopus.com/inward/record.url?scp=84892855554&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892855554&partnerID=8YFLogxK
U2 - 10.1016/j.jpain.2013.06.006
DO - 10.1016/j.jpain.2013.06.006
M3 - Article
C2 - 24275220
AN - SCOPUS:84892855554
SN - 1526-5900
VL - 14
SP - T2-T19
JO - Journal of Pain
JF - Journal of Pain
IS - 12 SUPPL.
ER -