TY - JOUR
T1 - Study of the origin of short- and long-latency SSEP during recovery from brain ischemia in a rat model
AU - Wu, Dan
AU - Anastassios, Bezerianos
AU - Xiong, Wei
AU - Madhok, Jai
AU - Jia, Xiaofeng
AU - Thakor, Nitish V.
N1 - Funding Information:
This work was supported by grants RO1 HL071568 from the National Institute of Health and 09SDG1110140 from the American Heart Association . The authors would like to thank Dr. Youngseok Choi and Huaijian Zhang for helpful discussions on signal processing.
PY - 2010/11/26
Y1 - 2010/11/26
N2 - Somatosensory evoked potentials (SSEPs) have been established as an electrophysiological tool for the prognostication of neurological outcome in patients with hypoxic-ischemic brain injury. The early and late responses in SSEPs reflect the sequential activation of neural structures along the somatosensory pathway. This study reports that the SSEP can be separated into early (short-latency, SL) and late (long-latency, LL) responses using independent component analysis (ICA), based on the assumption that these components are generated from different neural sources. Moreover, this source separation into the SL and LL components allows analysis of electrophysiological response to brain injury, even when the SSEPs are severely distorted and SL and LL components get mixed. With the help of ICA decomposition and corrected peak estimation, the latency of LL-SSEP is shown to be predictive of long-term neurological outcome. Further, it is shown that the recovery processes of SL- and LL-SSEPs follow different dynamics, with the SL-SSEP restored earlier than LL-SSEP. We predict that the SL- and LL-SSEPs reflect the timing of the progression of evoked response through the thalamocortical pathway and as such respond differently depending upon injury and recovery of the thalamic and cortical regions, respectively.
AB - Somatosensory evoked potentials (SSEPs) have been established as an electrophysiological tool for the prognostication of neurological outcome in patients with hypoxic-ischemic brain injury. The early and late responses in SSEPs reflect the sequential activation of neural structures along the somatosensory pathway. This study reports that the SSEP can be separated into early (short-latency, SL) and late (long-latency, LL) responses using independent component analysis (ICA), based on the assumption that these components are generated from different neural sources. Moreover, this source separation into the SL and LL components allows analysis of electrophysiological response to brain injury, even when the SSEPs are severely distorted and SL and LL components get mixed. With the help of ICA decomposition and corrected peak estimation, the latency of LL-SSEP is shown to be predictive of long-term neurological outcome. Further, it is shown that the recovery processes of SL- and LL-SSEPs follow different dynamics, with the SL-SSEP restored earlier than LL-SSEP. We predict that the SL- and LL-SSEPs reflect the timing of the progression of evoked response through the thalamocortical pathway and as such respond differently depending upon injury and recovery of the thalamic and cortical regions, respectively.
KW - Brain ischemia
KW - Independent component analysis
KW - Short/long-latency
KW - Somatosensory evoked potential
KW - Thalamocortical
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U2 - 10.1016/j.neulet.2010.08.086
DO - 10.1016/j.neulet.2010.08.086
M3 - Article
C2 - 20816917
AN - SCOPUS:77957885749
VL - 485
SP - 157
EP - 161
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -