Study of the anti-atherosclerotic mechanism of vitisin

Shao Jing Li, Feng Huang, Xi Lan, Guan Hua Du

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To elucidate the anti-atherosclerotic mechanism of vitisinA and didehydro-vitisinA from Vitis amurensis. Methods: After the human endothelial cell Hy926, monocyte derived THP-1 macrophage and mouse macrophage RAW264.7 were damaged by ox-LDL and LPS in vitro, the effects of the two test compounds were observed on cell viability by MTT reduction and LDH activity assay, the release of ROS and NO, the content of MDA, the activity of SOD, the secretion of inflammatory cytokines TNF-α and IL-1β, and the cell adhesion of THP-1 monocyte and endothelial cell Hy926. Results: The two compounds produced marked effects on protecting cells from injury, reducing the production of free radicals and the secretion of inflammatory cytokines, antioxcidation, and inhibiting the cell adhesion of monocyte and endothelial cells. Conclusions: It is observed that vitisinA and didehydro-vitisitiA can regulate factors which were important in the initiation and early progression of atherosclerosis, and their possible anti-atherosclerosis mechanism may be involved in multiple pathways.

Original languageEnglish (US)
Pages (from-to)1192-1198
Number of pages7
JournalChinese Pharmacological Bulletin
Volume26
Issue number9
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • Adhesion
  • Atherosclerosis
  • Endothelial cell
  • Macrophage
  • ox-LDL
  • Vitisin

ASJC Scopus subject areas

  • Pharmacology

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