Abstract
1 Rifampicin (RMP) induced hepatic injury was investi gated in growing rats. The interaction of moderate and severe protein-energy malnutrition (PEM) was also investigated. 2 Status of oxidative/antioxidative profile was studied by the mechanistic approach, to enumerate the nature of injury. 3 Successful hepatic injury in rats was produced by giving intraperitoneal injection of RMP (50 mg/kg/ day). 4 Hepatic lipid peroxidation was significantly increased in all the RMP treated rats. 5 Superoxide dismutase, catalase and glutathione per oxidase activities in the hepatic tissue decreased with RMP treatment. 6 Hepatic thiols represented as total and protein-bound thiols, showed significant elevation, whereas the non protein thiols remain unchanged with RMP treatment. 7 Glutathione-S-transferases also showed significant elevation against 1,2-dichloro-4 nitrobenzene (DCNB) and ethacrynic acid (EA) as substrates. 8 The oxidative/antioxidative profile was observed to be more severely affected with coexistence of malnutri tion. 9 Histopathological correlation showed an additional fatty infiltration of hepatocytes with coexistence of malnutrition. 10 Thus, in conclusion, it can be speculated that an altered oxidative/antioxidative profile is the closely associated with production of RMP induced hepatic injury.
Original language | English (US) |
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Pages (from-to) | 315-321 |
Number of pages | 7 |
Journal | Human & Experimental Toxicology |
Volume | 16 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1997 |
Externally published | Yes |
Keywords
- hepatotoxicity
- oxidative-stress
- protein- energy malnutrition
- rifampicin
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis