Study of occupation and amyotrophic lateral sclerosis in a Danish cohort

Aisha S. Dickerson, Johnni Hansen, Marianthi Anna Kioumourtzoglou, Aaron J. Specht, Ole Gredal, Marc G. Weisskopf

Research output: Contribution to journalArticlepeer-review


Objectives: Several manuscripts have proposed associations between amyotrophic lateral sclerosis (ALS) and occupational toxicant exposures - not to mention physical activity and trauma/injury. Some have also reported associations in investigations of specific occupations. Using data from a prospective Danish cohort study, we investigated the association between employment in certain industries and ALS diagnosis. Methods: We identified 1826 ALS cases who were 25 years old or less in 1964 and diagnosed from 1982 to 2013 from the Danish National Patient Registry then matched 100 population controls to each case based on birth year and sex. Demographic data were linked to the Danish Pension Fund to determine occupation history. Conditional logistic regression models were adjusted for socioeconomic status, marital status and residential location at the index date. Results: There was an increase in odds of ALS among men who worked in agriculture, hunting, forestry or fishing (adjusted OR (aOR)=1.21; 95% CI 1.02 to 1.45). There was also a positive association for men employed in construction (aOR=1.21; 95% CI 1.05 to 1.39). In women, a protective association was seen with employment in the cleaning industry (aOR=0.69; 95% CI 0.52 to 0.93). Conclusions: Our study shows various occupations with exposure to toxicants, such as diesel exhaust and lead, and strenuous physical activity associated with increased odds of ALS in men. Future studies should have a particular focus on gathering detailed information on physical exertion and toxicant exposures specific to certain job tasks.

Original languageEnglish (US)
Pages (from-to)630-638
Number of pages9
JournalOccupational and Environmental Medicine
Issue number9
StatePublished - Sep 2018
Externally publishedYes


  • amyotrophic lateral sclerosis
  • environment
  • epidemiology
  • international occupational health
  • neurodegeneration

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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