Study of near infrared imaging of a model of brain edema

Lee J. Johnson, Nitish Thakor, Daniel Hanley

Research output: Contribution to journalConference articlepeer-review

Abstract

Currently, methods for the detection of brain edema in patients or laboratory experiments are not ideal. MRI does not permit time resolution of injury and intracranial pressure monitoring is invasive. We have performed experiments on a model of brain edema to examine near infrared imaging as a convenient, low cost and noninvasive method of monitoring brain edema. We prepared an in vitro model of edema consisting of serial dilutions of Intralipid, a fat emulsion, to simulate varying degrees of brain water content. NIR light at two wavelengths (920 nm and 980 nm) was used to assess the water content of Intralipid. We obtained a correlation coefficient of 0.98 between water content and NIR absorption difference. We used the CCD system to image a model with spatial variations in water content. Our preliminary results suggest NIR spectroscopy as a useful technique for monitoring brain edema in both clinical and laboratory settings.

Original languageEnglish (US)
Pages (from-to)2107-2108
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume5
StatePublished - Dec 1 1996
EventProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth
Duration: Oct 31 1996Nov 3 1996

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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