Study of monocytes/macrophages stimuli as the targets of treating inflammatory bone diseases

Yuan Liu, Yang Cao, Wanli Smith, Baorong He, Liang Yan

Research output: Contribution to journalReview articlepeer-review

Abstract

Inflammation is the most common pathology in many orthopedic diseases, such as: rheumatoid arthritis (RA), osteoarthritis (OA) and other reasons caused osteolysis. The leading factor of inflammation was considered as the differentiation of monocyte and the polarization of macrophage. However, cytokines and different cell models could regulate this progress in some aspects. Therefore, in the current review, we summarize several cytokines and cell models, which could lead to inflammatory orthopedic diseases via regulating monocytes and macrophages. In order to extensively explore the potential therapeutic and medicine targets for inflammation-induced bone diseases.

Original languageEnglish (US)
Pages (from-to)338-343
Number of pages6
JournalCurrent Drug Targets
Volume21
Issue number4
DOIs
StatePublished - 2020

Keywords

  • Cytokines
  • Macrophages
  • Monocyte
  • Osteoarthritis
  • Osteolysis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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