Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy

Ezra E.W. Cohen, Omar Ahmed, Masha Kocherginsky, Galyna Shustakova, Emily Kistner-Griffin, Joseph K. Salama, Volodymyr Yefremenko, Valentyn Novosad

Research output: Contribution to journalArticle

Abstract

Background and Purpose Chemoradiotherapy (CRT) has led to improved efficacy in treating locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) but has led to almost universal in-field mucositis. Patients treated with the same regimen often have differences in mucositis occurrence and severity. Mucositis induced via radiation is known to represent an intense inflammatory response histologically. We hypothesized that patients destined to display severe mucocutaneous toxicity would demonstrate greater alterations in thermal intensity early in therapy than identically treated counterparts. This will allow identification of patients that will require more intensive supportive care using thermal imaging technology. Materials and methods Subjects with LA-SCCHN (oral cavity or oropharynx) being treated with the identical chemoradiotherapy regimen underwent baseline and weekly thermal imaging. Changes in skin temperature caused by mucositis and dermatitis compared with a reference area (ΔT were calculated and correlated to grade of mucositis based on NCI-CTCAE 3.0. Results Thirty-four subjects were enrolled. Grade 3 mucositis and dermatitis was observed in 53% and 21%, respectively. We observed a statistically significant positive association between an early rise in ΔT and mucositis grade (p value = 0.03). Conclusions Thermal imaging is able to detect small and early changes in skin surface temperature that may be associated with development of mucositis in patients being treated with chemoradiotherapy.

Original languageEnglish (US)
Pages (from-to)1025-1031
Number of pages7
JournalOral Oncology
Volume49
Issue number10
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

Fingerprint

Mucositis
Chemoradiotherapy
Head and Neck Neoplasms
Hot Temperature
Skin Temperature
Dermatitis
Oropharynx
Critical Care
Secondary Prevention
Mouth
Radiation
Technology

Keywords

  • Chemoradiation therapy
  • Head and neck cancer
  • Imaging
  • Mucositis

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy. / Cohen, Ezra E.W.; Ahmed, Omar; Kocherginsky, Masha; Shustakova, Galyna; Kistner-Griffin, Emily; Salama, Joseph K.; Yefremenko, Volodymyr; Novosad, Valentyn.

In: Oral Oncology, Vol. 49, No. 10, 01.10.2013, p. 1025-1031.

Research output: Contribution to journalArticle

Cohen, EEW, Ahmed, O, Kocherginsky, M, Shustakova, G, Kistner-Griffin, E, Salama, JK, Yefremenko, V & Novosad, V 2013, 'Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy', Oral Oncology, vol. 49, no. 10, pp. 1025-1031. https://doi.org/10.1016/j.oraloncology.2013.07.009
Cohen, Ezra E.W. ; Ahmed, Omar ; Kocherginsky, Masha ; Shustakova, Galyna ; Kistner-Griffin, Emily ; Salama, Joseph K. ; Yefremenko, Volodymyr ; Novosad, Valentyn. / Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy. In: Oral Oncology. 2013 ; Vol. 49, No. 10. pp. 1025-1031.
@article{e38f4ee050854f36996976ec9bb077d4,
title = "Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy",
abstract = "Background and Purpose Chemoradiotherapy (CRT) has led to improved efficacy in treating locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) but has led to almost universal in-field mucositis. Patients treated with the same regimen often have differences in mucositis occurrence and severity. Mucositis induced via radiation is known to represent an intense inflammatory response histologically. We hypothesized that patients destined to display severe mucocutaneous toxicity would demonstrate greater alterations in thermal intensity early in therapy than identically treated counterparts. This will allow identification of patients that will require more intensive supportive care using thermal imaging technology. Materials and methods Subjects with LA-SCCHN (oral cavity or oropharynx) being treated with the identical chemoradiotherapy regimen underwent baseline and weekly thermal imaging. Changes in skin temperature caused by mucositis and dermatitis compared with a reference area (ΔT were calculated and correlated to grade of mucositis based on NCI-CTCAE 3.0. Results Thirty-four subjects were enrolled. Grade 3 mucositis and dermatitis was observed in 53{\%} and 21{\%}, respectively. We observed a statistically significant positive association between an early rise in ΔT and mucositis grade (p value = 0.03). Conclusions Thermal imaging is able to detect small and early changes in skin surface temperature that may be associated with development of mucositis in patients being treated with chemoradiotherapy.",
keywords = "Chemoradiation therapy, Head and neck cancer, Imaging, Mucositis",
author = "Cohen, {Ezra E.W.} and Omar Ahmed and Masha Kocherginsky and Galyna Shustakova and Emily Kistner-Griffin and Salama, {Joseph K.} and Volodymyr Yefremenko and Valentyn Novosad",
year = "2013",
month = "10",
day = "1",
doi = "10.1016/j.oraloncology.2013.07.009",
language = "English (US)",
volume = "49",
pages = "1025--1031",
journal = "Oral Oncology",
issn = "1368-8375",
publisher = "Elsevier Limited",
number = "10",

}

TY - JOUR

T1 - Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy

AU - Cohen, Ezra E.W.

AU - Ahmed, Omar

AU - Kocherginsky, Masha

AU - Shustakova, Galyna

AU - Kistner-Griffin, Emily

AU - Salama, Joseph K.

AU - Yefremenko, Volodymyr

AU - Novosad, Valentyn

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Background and Purpose Chemoradiotherapy (CRT) has led to improved efficacy in treating locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) but has led to almost universal in-field mucositis. Patients treated with the same regimen often have differences in mucositis occurrence and severity. Mucositis induced via radiation is known to represent an intense inflammatory response histologically. We hypothesized that patients destined to display severe mucocutaneous toxicity would demonstrate greater alterations in thermal intensity early in therapy than identically treated counterparts. This will allow identification of patients that will require more intensive supportive care using thermal imaging technology. Materials and methods Subjects with LA-SCCHN (oral cavity or oropharynx) being treated with the identical chemoradiotherapy regimen underwent baseline and weekly thermal imaging. Changes in skin temperature caused by mucositis and dermatitis compared with a reference area (ΔT were calculated and correlated to grade of mucositis based on NCI-CTCAE 3.0. Results Thirty-four subjects were enrolled. Grade 3 mucositis and dermatitis was observed in 53% and 21%, respectively. We observed a statistically significant positive association between an early rise in ΔT and mucositis grade (p value = 0.03). Conclusions Thermal imaging is able to detect small and early changes in skin surface temperature that may be associated with development of mucositis in patients being treated with chemoradiotherapy.

AB - Background and Purpose Chemoradiotherapy (CRT) has led to improved efficacy in treating locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) but has led to almost universal in-field mucositis. Patients treated with the same regimen often have differences in mucositis occurrence and severity. Mucositis induced via radiation is known to represent an intense inflammatory response histologically. We hypothesized that patients destined to display severe mucocutaneous toxicity would demonstrate greater alterations in thermal intensity early in therapy than identically treated counterparts. This will allow identification of patients that will require more intensive supportive care using thermal imaging technology. Materials and methods Subjects with LA-SCCHN (oral cavity or oropharynx) being treated with the identical chemoradiotherapy regimen underwent baseline and weekly thermal imaging. Changes in skin temperature caused by mucositis and dermatitis compared with a reference area (ΔT were calculated and correlated to grade of mucositis based on NCI-CTCAE 3.0. Results Thirty-four subjects were enrolled. Grade 3 mucositis and dermatitis was observed in 53% and 21%, respectively. We observed a statistically significant positive association between an early rise in ΔT and mucositis grade (p value = 0.03). Conclusions Thermal imaging is able to detect small and early changes in skin surface temperature that may be associated with development of mucositis in patients being treated with chemoradiotherapy.

KW - Chemoradiation therapy

KW - Head and neck cancer

KW - Imaging

KW - Mucositis

UR - http://www.scopus.com/inward/record.url?scp=84884284826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884284826&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2013.07.009

DO - 10.1016/j.oraloncology.2013.07.009

M3 - Article

C2 - 23988569

AN - SCOPUS:84884284826

VL - 49

SP - 1025

EP - 1031

JO - Oral Oncology

JF - Oral Oncology

SN - 1368-8375

IS - 10

ER -