Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients

Joseph Meletiadis; Thomas J. Walsh; Eun Hwa Choi; Peter G. Pappas; David Ennis; Jeffrey Douglas; George A. Pankey; Robert A. Larsen; Richard J. Hamill; Stephen Chanock

doi:10.1080/13693780701390140

Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients

Joseph Meletiadis, Thomas J. Walsh, Eun Hwa Choi, Peter G. Pappas, David Ennis, Jeffrey Douglas, George A. Pankey, Robert A. Larsen, Richard J. Hamill, Stephen Chanock

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.

Original language	English (US)
Pages (from-to)	513-518
Number of pages	6
Journal	Medical mycology
Volume	45
Issue number	6
DOIs	https://doi.org/10.1080/13693780701390140
State	Published - Sep 2007
Externally published	Yes

Keywords

Candidate gene association studies
Cryptococcosis
Cryptococcus neoformans
Genetic polymorphisms
Haplotype analysis

ASJC Scopus subject areas

Infectious Diseases

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10.1080/13693780701390140

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title = "Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients",

abstract = "A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.",

keywords = "Candidate gene association studies, Cryptococcosis, Cryptococcus neoformans, Genetic polymorphisms, Haplotype analysis",

author = "Joseph Meletiadis and Walsh, {Thomas J.} and Choi, {Eun Hwa} and Pappas, {Peter G.} and David Ennis and Jeffrey Douglas and Pankey, {George A.} and Larsen, {Robert A.} and Hamill, {Richard J.} and Stephen Chanock",

note = "Funding Information: This research was supported by the Intramural Research Program of the NIH and National Cancer Institute.",

year = "2007",

month = sep,

doi = "10.1080/13693780701390140",

language = "English (US)",

volume = "45",

pages = "513--518",

journal = "Medical mycology",

issn = "1369-3786",

publisher = "Informa Healthcare",

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T1 - Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients

AU - Meletiadis, Joseph

AU - Walsh, Thomas J.

AU - Choi, Eun Hwa

AU - Pappas, Peter G.

AU - Ennis, David

AU - Douglas, Jeffrey

AU - Pankey, George A.

AU - Larsen, Robert A.

AU - Hamill, Richard J.

AU - Chanock, Stephen

N1 - Funding Information: This research was supported by the Intramural Research Program of the NIH and National Cancer Institute.

PY - 2007/9

Y1 - 2007/9

N2 - A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.

AB - A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.

KW - Candidate gene association studies

KW - Cryptococcosis

KW - Cryptococcus neoformans

KW - Genetic polymorphisms

KW - Haplotype analysis

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VL - 45

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JO - Medical mycology

JF - Medical mycology

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ER -

Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients

Abstract

Keywords

ASJC Scopus subject areas

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