Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients

Joseph Meletiadis, Thomas J. Walsh, Eun Hwa Choi, Peter G. Pappas, David Ennis, Jeffrey Douglas, George A. Pankey, Robert A. Larsen, Richard J. Hamill, Stephen Chanock

Research output: Contribution to journalArticle

Abstract

A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.

Original languageEnglish (US)
Pages (from-to)513-518
Number of pages6
JournalMedical mycology
Volume45
Issue number6
DOIs
StatePublished - Sep 1 2007

Keywords

  • Candidate gene association studies
  • Cryptococcosis
  • Cryptococcus neoformans
  • Genetic polymorphisms
  • Haplotype analysis

ASJC Scopus subject areas

  • Infectious Diseases

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    Meletiadis, J., Walsh, T. J., Choi, E. H., Pappas, P. G., Ennis, D., Douglas, J., Pankey, G. A., Larsen, R. A., Hamill, R. J., & Chanock, S. (2007). Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients. Medical mycology, 45(6), 513-518. https://doi.org/10.1080/13693780701390140