TY - JOUR
T1 - Study design and interim outcomes of Guangzhou Institute of respiratory disease COPD Biobank
AU - Lu, Wenju
AU - Zheng, Zeguang
AU - Chen, Xindong
AU - Tan, Hui
AU - Wang, Jian
AU - Zhang, Zili
AU - Zheng, Jinping
AU - Chen, Rongchang
AU - Zhang, Chenting
AU - Xu, Xiaoming
AU - Chen, Yuqin
AU - Yang, Quan
AU - Xiong, Mingmei
AU - Guo, Meihua
AU - Zhou, Qipeng
AU - Tang, Chun
AU - Wang, Yingfeng
AU - Ye, Jinmei
AU - Li, Defu
AU - Shu, Jiaze
AU - Tan, Shu
AU - Xu, Chuyi
AU - Wang, Yan
AU - Lai, Ning
AU - Yang, Kai
AU - Lu, Jiachun
AU - Ran, Pixin
AU - Zhong, Nanshan
N1 - Publisher Copyright:
© 2015 Taylor & Francis.
PY - 2016/3/3
Y1 - 2016/3/3
N2 - Background: GIRD COPD Biobank is a multicenter observational study blood-based database with local characteristics, in order to investigate the causes, risk factors, pathogenesis, prevalence patterns and trends of COPD and promote new pathogenic insights in China. Methods: We enrolled 855 clinically COPD patients and 660 controls with normal lung function. Extensive data collection has been undertaken with questionnaires, clinical measurements, and collection and storage of blood specimens, following Standard Operating Procedures (SOP). All surveys had similar quality controls, supervisions, and training of the investigator team. Results: Since September 2010, a total of 1515 subjects (1116 [73.7%] males; 855 [56.4%] diagnosed with COPD) were enrolled. Analyses of the design and interim results of the GIRD COPD Biobank Study identified patients with COPD were older, lower educational level, a longer history of pack-year smoking, less in kitchen fan usage, X-ray exposure, and history of disease (P < 0.01 for all); Most of the COPD subjects belonged to moderately severe or worse, stratified according to Global Lung Function Initiative (GLI); COPD patients had relatively more co-morbidities than controls; Environmental hazard exposures might be the main contributors to the reported respiratory symptoms; Cold air, haze, and influenza acted the top three factors to induce respiratory symptoms in both COPD cases and controls. Conclusion: The GIRD COPD Biobank Study has the potential to provide substantial novel insights into the genetics, biomarkers, environmental and lifestyle aspects of COPD. It is expected to provide new insights for pathogenesis and the long-term progression of COPD.
AB - Background: GIRD COPD Biobank is a multicenter observational study blood-based database with local characteristics, in order to investigate the causes, risk factors, pathogenesis, prevalence patterns and trends of COPD and promote new pathogenic insights in China. Methods: We enrolled 855 clinically COPD patients and 660 controls with normal lung function. Extensive data collection has been undertaken with questionnaires, clinical measurements, and collection and storage of blood specimens, following Standard Operating Procedures (SOP). All surveys had similar quality controls, supervisions, and training of the investigator team. Results: Since September 2010, a total of 1515 subjects (1116 [73.7%] males; 855 [56.4%] diagnosed with COPD) were enrolled. Analyses of the design and interim results of the GIRD COPD Biobank Study identified patients with COPD were older, lower educational level, a longer history of pack-year smoking, less in kitchen fan usage, X-ray exposure, and history of disease (P < 0.01 for all); Most of the COPD subjects belonged to moderately severe or worse, stratified according to Global Lung Function Initiative (GLI); COPD patients had relatively more co-morbidities than controls; Environmental hazard exposures might be the main contributors to the reported respiratory symptoms; Cold air, haze, and influenza acted the top three factors to induce respiratory symptoms in both COPD cases and controls. Conclusion: The GIRD COPD Biobank Study has the potential to provide substantial novel insights into the genetics, biomarkers, environmental and lifestyle aspects of COPD. It is expected to provide new insights for pathogenesis and the long-term progression of COPD.
KW - COPD
KW - biobank
KW - observational study
KW - respiratory diseases/symptoms
UR - http://www.scopus.com/inward/record.url?scp=84948739897&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84948739897&partnerID=8YFLogxK
U2 - 10.3109/15412555.2015.1069807
DO - 10.3109/15412555.2015.1069807
M3 - Article
C2 - 26625179
AN - SCOPUS:84948739897
SN - 1541-2555
VL - 13
SP - 203
EP - 213
JO - COPD: Journal of Chronic Obstructive Pulmonary Disease
JF - COPD: Journal of Chronic Obstructive Pulmonary Disease
IS - 2
ER -