Study design and interim outcomes of Guangzhou Institute of respiratory disease COPD Biobank

Wenju Lu, Zeguang Zheng, Xindong Chen, Hui Tan, Jian Wang, Zili Zhang, Jinping Zheng, Rongchang Chen, Chenting Zhang, Xiaoming Xu, Yuqin Chen, Quan Yang, Mingmei Xiong, Meihua Guo, Qipeng Zhou, Chun Tang, Yingfeng Wang, Jinmei Ye, Defu Li, Jiaze ShuShu Tan, Chuyi Xu, Yan Wang, Ning Lai, Kai Yang, Jiachun Lu, Pixin Ran, Nanshan Zhong

Research output: Contribution to journalArticlepeer-review

Abstract

Background: GIRD COPD Biobank is a multicenter observational study blood-based database with local characteristics, in order to investigate the causes, risk factors, pathogenesis, prevalence patterns and trends of COPD and promote new pathogenic insights in China. Methods: We enrolled 855 clinically COPD patients and 660 controls with normal lung function. Extensive data collection has been undertaken with questionnaires, clinical measurements, and collection and storage of blood specimens, following Standard Operating Procedures (SOP). All surveys had similar quality controls, supervisions, and training of the investigator team. Results: Since September 2010, a total of 1515 subjects (1116 [73.7%] males; 855 [56.4%] diagnosed with COPD) were enrolled. Analyses of the design and interim results of the GIRD COPD Biobank Study identified patients with COPD were older, lower educational level, a longer history of pack-year smoking, less in kitchen fan usage, X-ray exposure, and history of disease (P < 0.01 for all); Most of the COPD subjects belonged to moderately severe or worse, stratified according to Global Lung Function Initiative (GLI); COPD patients had relatively more co-morbidities than controls; Environmental hazard exposures might be the main contributors to the reported respiratory symptoms; Cold air, haze, and influenza acted the top three factors to induce respiratory symptoms in both COPD cases and controls. Conclusion: The GIRD COPD Biobank Study has the potential to provide substantial novel insights into the genetics, biomarkers, environmental and lifestyle aspects of COPD. It is expected to provide new insights for pathogenesis and the long-term progression of COPD.

Original languageEnglish (US)
Pages (from-to)203-213
Number of pages11
JournalCOPD: Journal of Chronic Obstructive Pulmonary Disease
Volume13
Issue number2
DOIs
StatePublished - Mar 3 2016

Keywords

  • COPD
  • biobank
  • observational study
  • respiratory diseases/symptoms

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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