Studies on type II collagen-induced polyarthritis in rats. Effect of antiinflammatory and antirheumatic agents

A. E. Sloboda, J. E. Birnbaum, A. L. Oronsky, S. S. Kerwar

Research output: Contribution to journalArticle

Abstract

The effect of a variety of antiinflammatory and antirheumatic agents on both developing and established lesions of type II collagen induced polyarthritis in rats was examined. Administration of the nonsteroidal antiinflammatory agents indomethacin or phenylbutazone suppressed the paw inflammation associated with the disease without affecting type II collagen antibody titers. Radiographic analysis of the joints showed suppression of several parameters related to joint destruction. This was most probably related to the antiinflammatory properties of the two drugs. Administration of prednisolone, a steroidal antiinflammatory agent, suppressed paw inflammation; type II collagen antibody titers were significantly decreased in the developing lesion, but the drug had no effect on antibody titers in the established lesion. Radiographic analysis of the joints showed decreases in several parameters of joint destruction. Cyclophosphamide, an immunosuppressive agent, completely suppressed the inflammation associated with the developing lesion but had only minimal effect against the established disease. Collagen antibody titers were decreased and an improvement in only one radiologic parameter (periostitis) was detected. Treatment with antirheumatic agent such as gold thioglucose or levamisole enhanced severity of inflammation in the established lesion and caused increases in collagen antibody titers. Radiographic analysis of the joints indicated an improvement in all parameters related to joint destruction in animals treated with penicillamine.

Original languageEnglish (US)
Pages (from-to)616-624
Number of pages9
JournalArthritis and Rheumatism
Volume24
Issue number4
StatePublished - 1981
Externally publishedYes

Fingerprint

Antirheumatic Agents
Collagen Type II
Arthritis
Anti-Inflammatory Agents
Joints
Antibodies
Inflammation
Collagen
Aurothioglucose
Periostitis
Phenylbutazone
Levamisole
Penicillamine
Non-Steroidal Anti-Inflammatory Agents
Immunosuppressive Agents
Prednisolone
Indomethacin
Pharmaceutical Preparations
Cyclophosphamide

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Sloboda, A. E., Birnbaum, J. E., Oronsky, A. L., & Kerwar, S. S. (1981). Studies on type II collagen-induced polyarthritis in rats. Effect of antiinflammatory and antirheumatic agents. Arthritis and Rheumatism, 24(4), 616-624.

Studies on type II collagen-induced polyarthritis in rats. Effect of antiinflammatory and antirheumatic agents. / Sloboda, A. E.; Birnbaum, J. E.; Oronsky, A. L.; Kerwar, S. S.

In: Arthritis and Rheumatism, Vol. 24, No. 4, 1981, p. 616-624.

Research output: Contribution to journalArticle

Sloboda, AE, Birnbaum, JE, Oronsky, AL & Kerwar, SS 1981, 'Studies on type II collagen-induced polyarthritis in rats. Effect of antiinflammatory and antirheumatic agents', Arthritis and Rheumatism, vol. 24, no. 4, pp. 616-624.
Sloboda, A. E. ; Birnbaum, J. E. ; Oronsky, A. L. ; Kerwar, S. S. / Studies on type II collagen-induced polyarthritis in rats. Effect of antiinflammatory and antirheumatic agents. In: Arthritis and Rheumatism. 1981 ; Vol. 24, No. 4. pp. 616-624.
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