Studies on type II collagen induced polyarthritis in rats. Effect of complement depletion

S. S. Kerwar; Norman Bauman; Arnold L. Oronsky; Adolph E. Sloboda

doi:10.3109/08923978109031065

Studies on type II collagen induced polyarthritis in rats. Effect of complement depletion

S. S. Kerwar, Norman Bauman, Arnold L. Oronsky, Adolph E. Sloboda

School of Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The effect of cobra venom factor on the developing and the established lesion of collagen-induced rat polyarthritis has been examined. In the developing lesion, decomplementation by cobra venom factor results in a delay in the onset of inflammation and a decrease in the radiological parameters of joint destruction. Under the conditions of the decomplementation, antibody titers to collagen are not decreased. In the established lesion, treatment with cobra venom factor has no effect, on either the inflammatory lesion or the various radiological parameters of joint destruction.

Original language	English (US)
Pages (from-to)	323-337
Number of pages	15
Journal	Immunopharmacology and Immunotoxicology
Volume	3
Issue number	3-4
DOIs	https://doi.org/10.3109/08923978109031065
State	Published - Jan 1 1981

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Toxicology
Pharmacology

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abstract = "The effect of cobra venom factor on the developing and the established lesion of collagen-induced rat polyarthritis has been examined. In the developing lesion, decomplementation by cobra venom factor results in a delay in the onset of inflammation and a decrease in the radiological parameters of joint destruction. Under the conditions of the decomplementation, antibody titers to collagen are not decreased. In the established lesion, treatment with cobra venom factor has no effect, on either the inflammatory lesion or the various radiological parameters of joint destruction.",

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AB - The effect of cobra venom factor on the developing and the established lesion of collagen-induced rat polyarthritis has been examined. In the developing lesion, decomplementation by cobra venom factor results in a delay in the onset of inflammation and a decrease in the radiological parameters of joint destruction. Under the conditions of the decomplementation, antibody titers to collagen are not decreased. In the established lesion, treatment with cobra venom factor has no effect, on either the inflammatory lesion or the various radiological parameters of joint destruction.

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Studies on type II collagen induced polyarthritis in rats. Effect of complement depletion

Abstract

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