Studies on type II collagen induced polyarthritis in rats. Effect of complement depletion

S. S. Kerwar, Norman Bauman, Arnold L. Oronsky, Adolph E. Sloboda

Research output: Contribution to journalArticle

Abstract

The effect of cobra venom factor on the developing and the established lesion of collagen-induced rat polyarthritis has been examined. In the developing lesion, decomplementation by cobra venom factor results in a delay in the onset of inflammation and a decrease in the radiological parameters of joint destruction. Under the conditions of the decomplementation, antibody titers to collagen are not decreased. In the established lesion, treatment with cobra venom factor has no effect, on either the inflammatory lesion or the various radiological parameters of joint destruction.

Original languageEnglish (US)
Pages (from-to)323-337
Number of pages15
JournalImmunopharmacology and Immunotoxicology
Volume3
Issue number3-4
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

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