Studies on the Walker Tumor II. Effects of Adrenalectomy and Hypophysectomy on Tumor Growth in Tube-fed Rats

Paul Talalay, G. M.V. Takano, Charles Huggins

Research output: Contribution to journalArticlepeer-review

Abstract

1. Bilateral adrenalectomy in tube-fed rats maintained with saline drinking water inhibits the growth of intramuscular Walker tumor implants to ca. 57 per cent of controls. 2. Hypophysectomy in tube-fed rats inhibits the growth of intramuscular Walker tumor implants to ca. 46 per cent of controls. 3. Cortisone acetate or adrenal cortical extract in doses used can only to a slight extent counteract the absence of the adrenals or pituitary. 4. Combined removal of adrenals and pituitary results in a cumulative restraint on tumor growth.

Original languageEnglish (US)
Pages (from-to)838-843
Number of pages6
JournalCancer Research
Volume12
Issue number11
StatePublished - Nov 1 1952

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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