4, 4′-(Adipyldioxyethyoxy) dibenzoic acid (la), 4, 4′-(sebacoyldioxyethyoxy ) dibenzoic acid(lb) and 4,4′-(benzoyldioxyethyoxy)dibenzoic acid(lc) were synthesized and converted into mixed anhydrides by the reaction with acetic anhydride. Poly ( esteranhydride)s 2a, 2b and 2c were yielded by subsequent melt polycondensation. Their chemical structures were confirmed by 1H NMR, IR, UV and elemental analysis. In vitro degradation of poly(ester-anhydride)s in phosphate buffer solution at 37 °C was determined. Drug release profile of Ciprofloxacin was also studied.
|Original language||English (US)|
|Journal||Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities|
|State||Published - Dec 1 1998|
- Drug controlled release
- Poly (ester-anhydride)
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