Abstract
4, 4′-(Adipyldioxyethyoxy) dibenzoic acid (la), 4, 4′-(sebacoyldioxyethyoxy ) dibenzoic acid(lb) and 4,4′-(benzoyldioxyethyoxy)dibenzoic acid(lc) were synthesized and converted into mixed anhydrides by the reaction with acetic anhydride. Poly ( esteranhydride)s 2a, 2b and 2c were yielded by subsequent melt polycondensation. Their chemical structures were confirmed by 1H NMR, IR, UV and elemental analysis. In vitro degradation of poly(ester-anhydride)s in phosphate buffer solution at 37 °C was determined. Drug release profile of Ciprofloxacin was also studied.
| Original language | English (US) |
|---|---|
| Pages (from-to) | x36-816 |
| Journal | Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities |
| Volume | 19 |
| Issue number | 5 |
| State | Published - Dec 1 1998 |
| Externally published | Yes |
Keywords
- Ciprofloxacin
- Drug controlled release
- Poly (ester-anhydride)
ASJC Scopus subject areas
- General Chemistry