Studies on the syntheses and properties of poly(ester-anhydride)s for DDS

Jie Fu, Ren Xi Zhuo, Chang Lie Fan

Research output: Contribution to journalArticlepeer-review

Abstract

4, 4′-(Adipyldioxyethyoxy) dibenzoic acid (la), 4, 4′-(sebacoyldioxyethyoxy ) dibenzoic acid(lb) and 4,4′-(benzoyldioxyethyoxy)dibenzoic acid(lc) were synthesized and converted into mixed anhydrides by the reaction with acetic anhydride. Poly ( esteranhydride)s 2a, 2b and 2c were yielded by subsequent melt polycondensation. Their chemical structures were confirmed by 1H NMR, IR, UV and elemental analysis. In vitro degradation of poly(ester-anhydride)s in phosphate buffer solution at 37 °C was determined. Drug release profile of Ciprofloxacin was also studied.

Original languageEnglish (US)
Pages (from-to)x36-816
JournalKao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
Volume19
Issue number5
StatePublished - Dec 1 1998
Externally publishedYes

Keywords

  • Ciprofloxacin
  • Drug controlled release
  • Poly (ester-anhydride)

ASJC Scopus subject areas

  • Chemistry(all)

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