Studies on the syntheses and properties of phosphorus-containing polyanhydrides for DDS

Jie Fu, Ren Xi Zhuo, Chang Lie Fan

Research output: Contribution to journalArticle

Abstract

Phosphorus-containing polyanhydrides (2a, 2b) and copolyanhydrides (1a-CPP, 1b-CPP) were synthesized by melt polycondensation using monomers bis (p-carboxypheny-loxyethyl), ethyl phosphate and bis (p-carboxyphenyloxyethyl), phenyl phosphate. Their chemical structures were confirmed by 1H NMR, FTIR, UV and elementary analysis. The average molecular weight and store stability as well as thermostability of these polyanhydries and copolyanhydrides were investigated. The degradation of polyanhydrides in vitro in phosphate buffer solution at 37 °C was monitored by HPLC. The experimental data revealed that fission of phosphate bond took place after that of the anhydride bond. Enzymatic degradation showed that ribonuclease and alkaline phosphatase can catalyze and accelerate the degradation of these phosphorus-cotaning polyanhydrides. Drug release profile of ciprofloxacin was also studied.

Original languageEnglish (US)
JournalKao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
Volume18
Issue number5
StatePublished - 1997
Externally publishedYes

Fingerprint

Polyanhydrides
Phosphorus
Phosphates
Degradation
Anhydrides
Polycondensation
Ciprofloxacin
Alkaline Phosphatase
Buffers
Monomers
Molecular weight
Nuclear magnetic resonance
Pharmaceutical Preparations

Keywords

  • Ciprofloxacin
  • Drug controlled release
  • Polyanhydride
  • Polyphosphate

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

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abstract = "Phosphorus-containing polyanhydrides (2a, 2b) and copolyanhydrides (1a-CPP, 1b-CPP) were synthesized by melt polycondensation using monomers bis (p-carboxypheny-loxyethyl), ethyl phosphate and bis (p-carboxyphenyloxyethyl), phenyl phosphate. Their chemical structures were confirmed by 1H NMR, FTIR, UV and elementary analysis. The average molecular weight and store stability as well as thermostability of these polyanhydries and copolyanhydrides were investigated. The degradation of polyanhydrides in vitro in phosphate buffer solution at 37 °C was monitored by HPLC. The experimental data revealed that fission of phosphate bond took place after that of the anhydride bond. Enzymatic degradation showed that ribonuclease and alkaline phosphatase can catalyze and accelerate the degradation of these phosphorus-cotaning polyanhydrides. Drug release profile of ciprofloxacin was also studied.",
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AU - Fu, Jie

AU - Zhuo, Ren Xi

AU - Fan, Chang Lie

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N2 - Phosphorus-containing polyanhydrides (2a, 2b) and copolyanhydrides (1a-CPP, 1b-CPP) were synthesized by melt polycondensation using monomers bis (p-carboxypheny-loxyethyl), ethyl phosphate and bis (p-carboxyphenyloxyethyl), phenyl phosphate. Their chemical structures were confirmed by 1H NMR, FTIR, UV and elementary analysis. The average molecular weight and store stability as well as thermostability of these polyanhydries and copolyanhydrides were investigated. The degradation of polyanhydrides in vitro in phosphate buffer solution at 37 °C was monitored by HPLC. The experimental data revealed that fission of phosphate bond took place after that of the anhydride bond. Enzymatic degradation showed that ribonuclease and alkaline phosphatase can catalyze and accelerate the degradation of these phosphorus-cotaning polyanhydrides. Drug release profile of ciprofloxacin was also studied.

AB - Phosphorus-containing polyanhydrides (2a, 2b) and copolyanhydrides (1a-CPP, 1b-CPP) were synthesized by melt polycondensation using monomers bis (p-carboxypheny-loxyethyl), ethyl phosphate and bis (p-carboxyphenyloxyethyl), phenyl phosphate. Their chemical structures were confirmed by 1H NMR, FTIR, UV and elementary analysis. The average molecular weight and store stability as well as thermostability of these polyanhydries and copolyanhydrides were investigated. The degradation of polyanhydrides in vitro in phosphate buffer solution at 37 °C was monitored by HPLC. The experimental data revealed that fission of phosphate bond took place after that of the anhydride bond. Enzymatic degradation showed that ribonuclease and alkaline phosphatase can catalyze and accelerate the degradation of these phosphorus-cotaning polyanhydrides. Drug release profile of ciprofloxacin was also studied.

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