Phosphorus-containing polyanhydrides (2a, 2b) and copolyanhydrides (1a-CPP, 1b-CPP) were synthesized by melt polycondensation using monomers bis (p-carboxypheny-loxyethyl), ethyl phosphate and bis (p-carboxyphenyloxyethyl), phenyl phosphate. Their chemical structures were confirmed by 1H NMR, FTIR, UV and elementary analysis. The average molecular weight and store stability as well as thermostability of these polyanhydries and copolyanhydrides were investigated. The degradation of polyanhydrides in vitro in phosphate buffer solution at 37 °C was monitored by HPLC. The experimental data revealed that fission of phosphate bond took place after that of the anhydride bond. Enzymatic degradation showed that ribonuclease and alkaline phosphatase can catalyze and accelerate the degradation of these phosphorus-cotaning polyanhydrides. Drug release profile of ciprofloxacin was also studied.
|Original language||English (US)|
|Journal||Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities|
|State||Published - Dec 1 1997|
- Drug controlled release
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