Studies on the synergy between collagen and adjuvant arthritis in rats

Susan Quinn DeJoy; Kim M. Ferguson; Arnold L. Oronsky; S. S. Kerwar

doi:10.1016/0008-8749(88)90011-1

Studies on the synergy between collagen and adjuvant arthritis in rats

Susan Quinn DeJoy, Kim M. Ferguson, Arnold L. Oronsky, S. S. Kerwar

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Intravenous administration of subarthritogenic doses of anticollagen IgG and adjuvant-sensitized spleen cells to syngeneic naive rats induces an erosive arthritis in recipients. The onset of the clinical disease in recipients is rapid and the disease is severe when compared to those recipients receiving cells alone. Immunocytochemical analysis of the knee synovium indicates the accumulation in the adipose tissue of Ia⁺ (ED1⁺)macrophages, OX-19⁺ T lymphocytes, and neutrophils. A large proportion of the lining cells of the proliferative synovium are Ia⁺. The knee synovium is extremely edematous and contains fibrin. If recipient rats are decomplemented, clinical disease is delayed and the number of mononuclear and polymorphonuclear cells accumulating in the synovium is decreased. Similar results are observed if recipient rats are treated with anti-Ia⁺ antibody. However, anti-Ia⁺ treatment does not induce depletion of serum complement.

Original language	English (US)
Pages (from-to)	117-129
Number of pages	13
Journal	Cellular Immunology
Volume	113
Issue number	1
DOIs	https://doi.org/10.1016/0008-8749(88)90011-1
State	Published - Apr 15 1988
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/0008-8749(88)90011-1

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title = "Studies on the synergy between collagen and adjuvant arthritis in rats",

abstract = "Intravenous administration of subarthritogenic doses of anticollagen IgG and adjuvant-sensitized spleen cells to syngeneic naive rats induces an erosive arthritis in recipients. The onset of the clinical disease in recipients is rapid and the disease is severe when compared to those recipients receiving cells alone. Immunocytochemical analysis of the knee synovium indicates the accumulation in the adipose tissue of Ia+ (ED1+)macrophages, OX-19+ T lymphocytes, and neutrophils. A large proportion of the lining cells of the proliferative synovium are Ia+. The knee synovium is extremely edematous and contains fibrin. If recipient rats are decomplemented, clinical disease is delayed and the number of mononuclear and polymorphonuclear cells accumulating in the synovium is decreased. Similar results are observed if recipient rats are treated with anti-Ia+ antibody. However, anti-Ia+ treatment does not induce depletion of serum complement.",

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AU - DeJoy, Susan Quinn

AU - Ferguson, Kim M.

AU - Oronsky, Arnold L.

AU - Kerwar, S. S.

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Y1 - 1988/4/15

N2 - Intravenous administration of subarthritogenic doses of anticollagen IgG and adjuvant-sensitized spleen cells to syngeneic naive rats induces an erosive arthritis in recipients. The onset of the clinical disease in recipients is rapid and the disease is severe when compared to those recipients receiving cells alone. Immunocytochemical analysis of the knee synovium indicates the accumulation in the adipose tissue of Ia+ (ED1+)macrophages, OX-19+ T lymphocytes, and neutrophils. A large proportion of the lining cells of the proliferative synovium are Ia+. The knee synovium is extremely edematous and contains fibrin. If recipient rats are decomplemented, clinical disease is delayed and the number of mononuclear and polymorphonuclear cells accumulating in the synovium is decreased. Similar results are observed if recipient rats are treated with anti-Ia+ antibody. However, anti-Ia+ treatment does not induce depletion of serum complement.

AB - Intravenous administration of subarthritogenic doses of anticollagen IgG and adjuvant-sensitized spleen cells to syngeneic naive rats induces an erosive arthritis in recipients. The onset of the clinical disease in recipients is rapid and the disease is severe when compared to those recipients receiving cells alone. Immunocytochemical analysis of the knee synovium indicates the accumulation in the adipose tissue of Ia+ (ED1+)macrophages, OX-19+ T lymphocytes, and neutrophils. A large proportion of the lining cells of the proliferative synovium are Ia+. The knee synovium is extremely edematous and contains fibrin. If recipient rats are decomplemented, clinical disease is delayed and the number of mononuclear and polymorphonuclear cells accumulating in the synovium is decreased. Similar results are observed if recipient rats are treated with anti-Ia+ antibody. However, anti-Ia+ treatment does not induce depletion of serum complement.

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Studies on the synergy between collagen and adjuvant arthritis in rats

Abstract

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