Studies on the relationship of the release of serotonin and histamine, by chemical means, to anaphylaxis in the rabbit

T. Phillip Waalkes, Harriette Coburn

Research output: Contribution to journalArticle

Abstract

Anaphylaxis in the rabbit is accompanied by a drop in the whole-blood serotonin and histamine, a release of these amines into the plasma, and a rise in their concentration in the lung. When antigen is added to the blood from a sensitized rabbit, serotonin and histamine are released. If EDTA is used as an anticoagulant, however, the release is prevented. In this study a variety of materials were tested, both in vitro with rabbit whole blood and in vivo by intravenous injection, to determine whether or not any of them could duplicate the findings which occur during anaphylaxis. Of all the substances employed, glycogen reproduced exactly the changes in platelets, serotonin, and histamine seen after the intravenous injection of antigen-antibody complex into normal rabbits or during anaphylactic reaction in this species.

Original languageEnglish (US)
Pages (from-to)395-405
Number of pages11
JournalJournal of Allergy
Volume31
Issue number5
StatePublished - Sep 1960
Externally publishedYes

Fingerprint

Histamine Release
Anaphylaxis
Serotonin
Rabbits
Intravenous Injections
Histamine
Antigen-Antibody Complex
Glycogen
Edetic Acid
Anticoagulants
Amines
Blood Platelets
Antigens
Lung

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Studies on the relationship of the release of serotonin and histamine, by chemical means, to anaphylaxis in the rabbit. / Waalkes, T. Phillip; Coburn, Harriette.

In: Journal of Allergy, Vol. 31, No. 5, 09.1960, p. 395-405.

Research output: Contribution to journalArticle

@article{f146ed5cf0e0410a9e3bf8c0e52fc5c2,
title = "Studies on the relationship of the release of serotonin and histamine, by chemical means, to anaphylaxis in the rabbit",
abstract = "Anaphylaxis in the rabbit is accompanied by a drop in the whole-blood serotonin and histamine, a release of these amines into the plasma, and a rise in their concentration in the lung. When antigen is added to the blood from a sensitized rabbit, serotonin and histamine are released. If EDTA is used as an anticoagulant, however, the release is prevented. In this study a variety of materials were tested, both in vitro with rabbit whole blood and in vivo by intravenous injection, to determine whether or not any of them could duplicate the findings which occur during anaphylaxis. Of all the substances employed, glycogen reproduced exactly the changes in platelets, serotonin, and histamine seen after the intravenous injection of antigen-antibody complex into normal rabbits or during anaphylactic reaction in this species.",
author = "Waalkes, {T. Phillip} and Harriette Coburn",
year = "1960",
month = "9",
language = "English (US)",
volume = "31",
pages = "395--405",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Studies on the relationship of the release of serotonin and histamine, by chemical means, to anaphylaxis in the rabbit

AU - Waalkes, T. Phillip

AU - Coburn, Harriette

PY - 1960/9

Y1 - 1960/9

N2 - Anaphylaxis in the rabbit is accompanied by a drop in the whole-blood serotonin and histamine, a release of these amines into the plasma, and a rise in their concentration in the lung. When antigen is added to the blood from a sensitized rabbit, serotonin and histamine are released. If EDTA is used as an anticoagulant, however, the release is prevented. In this study a variety of materials were tested, both in vitro with rabbit whole blood and in vivo by intravenous injection, to determine whether or not any of them could duplicate the findings which occur during anaphylaxis. Of all the substances employed, glycogen reproduced exactly the changes in platelets, serotonin, and histamine seen after the intravenous injection of antigen-antibody complex into normal rabbits or during anaphylactic reaction in this species.

AB - Anaphylaxis in the rabbit is accompanied by a drop in the whole-blood serotonin and histamine, a release of these amines into the plasma, and a rise in their concentration in the lung. When antigen is added to the blood from a sensitized rabbit, serotonin and histamine are released. If EDTA is used as an anticoagulant, however, the release is prevented. In this study a variety of materials were tested, both in vitro with rabbit whole blood and in vivo by intravenous injection, to determine whether or not any of them could duplicate the findings which occur during anaphylaxis. Of all the substances employed, glycogen reproduced exactly the changes in platelets, serotonin, and histamine seen after the intravenous injection of antigen-antibody complex into normal rabbits or during anaphylactic reaction in this species.

UR - http://www.scopus.com/inward/record.url?scp=49749211334&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49749211334&partnerID=8YFLogxK

M3 - Article

C2 - 13782348

AN - SCOPUS:49749211334

VL - 31

SP - 395

EP - 405

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5

ER -