Studies on the relationship between toxin anaphylaxis and antitoxic immunity: II. Significance of the relation between the tissue antitoxin and circulating antitoxin on the toxin anaphylaxis and antitoxic immunity

1) In the guinea pigs actively immunized with alum-precipitated diphthe rial toxoid, the relationship between the concentration of circulating antitoxin and the degree of sensitization varies depending on the period after immunization. Namely, at an early period the degree of sensitization is relatively high in spite of the low concentration of circulating antitoxin. 2) The relationship between the schick level and the concentration of the circulating antitoxin in these guinea pigs differs depending on the period after immunization. 3) Moreover, the ratio of the tissue antitoxin extracted from skin to the concentration of the circulating antitoxin varies depending on the period after immunization. Namely, the ratio at the early period is relatively high as compared with the ratio at the later period. 4) Such a change of ratio would be one of the most important reason why the relation between immunity and allergy is divergent depending on the experimental condition. The authors wish to express their gratitude for cordial guidance of Prof. K. Nakamura.