TY - JOUR
T1 - Studies on the relationship between toxin anaphylaxis and antitoxic immunity
T2 - II. Significance of the relation between the tissue antitoxin and circulating antitoxin on the toxin anaphylaxis and antitoxic immunity
AU - Ishizaka, Kimishige
AU - Ishizaka, Teruko
AU - Sugahara, Takao
PY - 1955/1/1
Y1 - 1955/1/1
N2 - 1) In the guinea pigs actively immunized with alum-precipitated diphthe rial toxoid, the relationship between the concentration of circulating antitoxin and the degree of sensitization varies depending on the period after immunization. Namely, at an early period the degree of sensitization is relatively high in spite of the low concentration of circulating antitoxin. 2) The relationship between the schick level and the concentration of the circulating antitoxin in these guinea pigs differs depending on the period after immunization. 3) Moreover, the ratio of the tissue antitoxin extracted from skin to the concentration of the circulating antitoxin varies depending on the period after immunization. Namely, the ratio at the early period is relatively high as compared with the ratio at the later period. 4) Such a change of ratio would be one of the most important reason why the relation between immunity and allergy is divergent depending on the experimental condition. The authors wish to express their gratitude for cordial guidance of Prof. K. Nakamura.
AB - 1) In the guinea pigs actively immunized with alum-precipitated diphthe rial toxoid, the relationship between the concentration of circulating antitoxin and the degree of sensitization varies depending on the period after immunization. Namely, at an early period the degree of sensitization is relatively high in spite of the low concentration of circulating antitoxin. 2) The relationship between the schick level and the concentration of the circulating antitoxin in these guinea pigs differs depending on the period after immunization. 3) Moreover, the ratio of the tissue antitoxin extracted from skin to the concentration of the circulating antitoxin varies depending on the period after immunization. Namely, the ratio at the early period is relatively high as compared with the ratio at the later period. 4) Such a change of ratio would be one of the most important reason why the relation between immunity and allergy is divergent depending on the experimental condition. The authors wish to express their gratitude for cordial guidance of Prof. K. Nakamura.
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U2 - 10.7883/yoken1952.8.283
DO - 10.7883/yoken1952.8.283
M3 - Article
C2 - 13285965
AN - SCOPUS:84961010237
VL - 8
SP - 283
EP - 293
JO - Japanese medical journal
JF - Japanese medical journal
SN - 1344-6304
IS - 3
ER -