Studies on the relationship between toxin-anaphylaxis and antitoxic immunity: I. quantitative studies on the toxin-anaphylaxis in vitro

1) Inhibition due to antigen excess or antibody excess was not observed in the anaphylactic contraction of guinea pig intestine. 2) The more the amount of antitoxin exsisted in the tissues, the less amount of toxoid is required to cause the anaphylactic contraction of the same intensity. Moreover, a certain correlation is assumed between the amount of antitoxin in the tissues and the reciprocal of the dosis of toxoid required to cause the anaphylactic contraction. 3) Non-precipitating antitoxin of guinea pig is incapable of sensitizing guinea pig intestine. The authors wish to express their gratitude for cordial guidance of Prof. K. Nakamura of the National Institute of Health.