Studies on the melt copolymerization of phosphorus-containing diacid and BIS(p-carboxyphenoxy) propand for DDS

Jie Fu, Renxi Zhuo, Changlie Fan

Research output: Contribution to journalArticle

Abstract

Phosphorus containing copolyanhydrides DECP-CPP and DCPP-CPP were synthesized by melt copolymerization of bis(p-carboxy phenyloxy ethyl), ethyl phosphate (DCPE), bis(p-carboxyphenyloxy ethyl), phenyl phosphate (DCPP) and bis(p-carboxyphenoxy)propane acid (CPP). The copolyanhydrides were characterized by 1H NMR, IR spectrometry. In Vitro degradation of copolyanhydrides in phosphate buffer solution at 37°C were determined. Drug release profile of Rifampicinum (RFP) were also studied.

Original languageEnglish (US)
Pages (from-to)X11-470
JournalWuhan Daxue Xuebao/Journal of Wuhan University
Volume43
Issue number4
StatePublished - Dec 1 1997
Externally publishedYes

Keywords

  • Copolyanhydride
  • Drug controlled release
  • Polyphosphate
  • RFP

ASJC Scopus subject areas

  • Management of Technology and Innovation

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