Abstract
The efficacy of glucocorticoids in the treatment of allergic diseases is well established. Among their observed beneficial effects is the ability to reduce the appearance of eosinophils and eosinophil-derived mediators at sites of allergic inflammation. How glucocorticoids prevent eosinophil influx in vivo is not completely understood, but may include effects on various aspects of eosi-nophil recruitment. Studies examining the effects of glucocorticoids on (1) eosinophil survival, (2) eosinophil and endothelial adhesion responses, (3) the production of endothelial-activating and eosinophil-priming cytokines, and (4) eosinophil chemotactic factor responsiveness, will be reviewed. It is likely that the potent ability of glucocorticoids to prevent eosinophil emigration into tissue sites results from a combination of both direct and indirect effects on the eosinophil, the endothelium, and other cells involved in the production of pro-inflammatory mediators responsible for eosinophil infiltration.
Original language | English (US) |
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Pages (from-to) | 289-294 |
Number of pages | 6 |
Journal | International archives of allergy and immunology |
Volume | 99 |
Issue number | 2-4 |
DOIs | |
State | Published - 1992 |
Keywords
- Adhesion molecules
- Cytokines
- Endothelial cells
- Eosinophils
- Glucocorticoids
- Priming
- Survival
- Transendothelial migration
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology