Studies on the mechanisms by which glucocorticoids inhibit tissue eosinophilia in allergic reactions

Robert P. Schleimer, James Kaiser, Kenichi Tomioka, Motohiro Ebisawa, Bruce S. Bochner

Research output: Contribution to journalArticlepeer-review


The efficacy of glucocorticoids in the treatment of allergic diseases is well established. Among their observed beneficial effects is the ability to reduce the appearance of eosinophils and eosinophil-derived mediators at sites of allergic inflammation. How glucocorticoids prevent eosinophil influx in vivo is not completely understood, but may include effects on various aspects of eosi-nophil recruitment. Studies examining the effects of glucocorticoids on (1) eosinophil survival, (2) eosinophil and endothelial adhesion responses, (3) the production of endothelial-activating and eosinophil-priming cytokines, and (4) eosinophil chemotactic factor responsiveness, will be reviewed. It is likely that the potent ability of glucocorticoids to prevent eosinophil emigration into tissue sites results from a combination of both direct and indirect effects on the eosinophil, the endothelium, and other cells involved in the production of pro-inflammatory mediators responsible for eosinophil infiltration.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalInternational archives of allergy and immunology
Issue number2-4
StatePublished - 1992


  • Adhesion molecules
  • Cytokines
  • Endothelial cells
  • Eosinophils
  • Glucocorticoids
  • Priming
  • Survival
  • Transendothelial migration

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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