Studies on the homing of Mycobacterium-sensitized T lymphocytes to the synovium during passive adjuvant arthritis

Susan Quinn deJoy, Kim Ferguson-Chanowitz, Arnold L. Oronsky, John B. Zabriskie, S. S. Kerwar

Research output: Contribution to journalArticlepeer-review

Abstract

The migration of intravenously administered adjuvant sensitized T lymphocytes to the knee synovium of recipient rats undergoing passive adjuvant arthritis has been followed. Using fluorescein isothiocyanate (FITC)-labeled adjuvant-sensitized T cells and anticollagen IgG, the present studies demonstrate the presence of fluorescent cells in the inflamed knee synovium of recipient rats undergoing passive arthritis. Proliferation studies indicate that synovial cells from these rats respond to Mycobacterium tuberculosis (MT). Since cross-reactivity between Mycobacterial antigens and cartilage proteoglycans has been previously demonstrated, it is suggested that adjuvant-sensitized T cells that are injected into naive rats migrate to the synovium, proliferate in response to cartilage proteoglycan, and initiate passive arthritis.

Original languageEnglish (US)
Pages (from-to)195-203
Number of pages9
JournalCellular Immunology
Volume130
Issue number1
DOIs
StatePublished - Oct 1 1990

ASJC Scopus subject areas

  • Immunology

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