Studies on the effect of low dose methotrexate on rat adjuvant arthritis

W. L. Welles, J. Silkworth, A. L. Oronsky, S. S. Kerwar, J. Galivan

Research output: Contribution to journalArticle

Abstract

Adjuvant arthritis in rats was induced by the intradermal administration of Freund's complete adjuvant. When these immunized rats were treated orally with low doses of methotrexate (150-600 μg/kg/week) a statistically significant suppression of paw inflammation was observed. This low dose of methotrexate was comparable to that used in the treatment of human rheumatoid arthritis (RA). Our results are the first demonstration of the efficacy of low dose methotrexate in an animal model of human RA.

Original languageEnglish (US)
Pages (from-to)904-906
Number of pages3
JournalJournal of Rheumatology
Volume12
Issue number5
StatePublished - 1985
Externally publishedYes

Fingerprint

Experimental Arthritis
Methotrexate
Rheumatoid Arthritis
Freund's Adjuvant
Animal Models
Inflammation

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Welles, W. L., Silkworth, J., Oronsky, A. L., Kerwar, S. S., & Galivan, J. (1985). Studies on the effect of low dose methotrexate on rat adjuvant arthritis. Journal of Rheumatology, 12(5), 904-906.

Studies on the effect of low dose methotrexate on rat adjuvant arthritis. / Welles, W. L.; Silkworth, J.; Oronsky, A. L.; Kerwar, S. S.; Galivan, J.

In: Journal of Rheumatology, Vol. 12, No. 5, 1985, p. 904-906.

Research output: Contribution to journalArticle

Welles, WL, Silkworth, J, Oronsky, AL, Kerwar, SS & Galivan, J 1985, 'Studies on the effect of low dose methotrexate on rat adjuvant arthritis', Journal of Rheumatology, vol. 12, no. 5, pp. 904-906.
Welles WL, Silkworth J, Oronsky AL, Kerwar SS, Galivan J. Studies on the effect of low dose methotrexate on rat adjuvant arthritis. Journal of Rheumatology. 1985;12(5):904-906.
Welles, W. L. ; Silkworth, J. ; Oronsky, A. L. ; Kerwar, S. S. ; Galivan, J. / Studies on the effect of low dose methotrexate on rat adjuvant arthritis. In: Journal of Rheumatology. 1985 ; Vol. 12, No. 5. pp. 904-906.
@article{35bf8e56ce274f108a847232fb56d4c1,
title = "Studies on the effect of low dose methotrexate on rat adjuvant arthritis",
abstract = "Adjuvant arthritis in rats was induced by the intradermal administration of Freund's complete adjuvant. When these immunized rats were treated orally with low doses of methotrexate (150-600 μg/kg/week) a statistically significant suppression of paw inflammation was observed. This low dose of methotrexate was comparable to that used in the treatment of human rheumatoid arthritis (RA). Our results are the first demonstration of the efficacy of low dose methotrexate in an animal model of human RA.",
author = "Welles, {W. L.} and J. Silkworth and Oronsky, {A. L.} and Kerwar, {S. S.} and J. Galivan",
year = "1985",
language = "English (US)",
volume = "12",
pages = "904--906",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "5",

}

TY - JOUR

T1 - Studies on the effect of low dose methotrexate on rat adjuvant arthritis

AU - Welles, W. L.

AU - Silkworth, J.

AU - Oronsky, A. L.

AU - Kerwar, S. S.

AU - Galivan, J.

PY - 1985

Y1 - 1985

N2 - Adjuvant arthritis in rats was induced by the intradermal administration of Freund's complete adjuvant. When these immunized rats were treated orally with low doses of methotrexate (150-600 μg/kg/week) a statistically significant suppression of paw inflammation was observed. This low dose of methotrexate was comparable to that used in the treatment of human rheumatoid arthritis (RA). Our results are the first demonstration of the efficacy of low dose methotrexate in an animal model of human RA.

AB - Adjuvant arthritis in rats was induced by the intradermal administration of Freund's complete adjuvant. When these immunized rats were treated orally with low doses of methotrexate (150-600 μg/kg/week) a statistically significant suppression of paw inflammation was observed. This low dose of methotrexate was comparable to that used in the treatment of human rheumatoid arthritis (RA). Our results are the first demonstration of the efficacy of low dose methotrexate in an animal model of human RA.

UR - http://www.scopus.com/inward/record.url?scp=0022379424&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022379424&partnerID=8YFLogxK

M3 - Article

C2 - 4087270

AN - SCOPUS:0022379424

VL - 12

SP - 904

EP - 906

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 5

ER -