Studies on the effect of low dose methotrexate on rat adjuvant arthritis

W. L. Welles, J. Silkworth, A. L. Oronsky, S. S. Kerwar, J. Galivan

Research output: Contribution to journalArticlepeer-review


Adjuvant arthritis in rats was induced by the intradermal administration of Freund's complete adjuvant. When these immunized rats were treated orally with low doses of methotrexate (150-600 μg/kg/week) a statistically significant suppression of paw inflammation was observed. This low dose of methotrexate was comparable to that used in the treatment of human rheumatoid arthritis (RA). Our results are the first demonstration of the efficacy of low dose methotrexate in an animal model of human RA.

Original languageEnglish (US)
Pages (from-to)904-906
Number of pages3
JournalJournal of Rheumatology
Issue number5
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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