Studies on the effect of D-penicillamine on type II collagen-induced polyarthritis

S. S. Kerwar, A. E. Sloboda, J. E. Birnbaum, A. L. Oronsky

Research output: Contribution to journalArticle

Abstract

The effect of D-penicillamine on a preestablished lesion of type II collagen-induced polyarthritis is reviewed. D-penicillamine treatment (100 and 200 mg/kg/d) for 21 d had no significant effect on rat hind paw inflammation associated with this polyarthritis. At the lower dose, the drug caused an increase in circulating antibody titers to type II collagen. X-ray examination of the hind paws of D-penicillamine-treated animals showed a significant improvement in the joint lesions induced by type II collagen.

Original languageEnglish (US)
Pages (from-to)84-89
Number of pages6
JournalJournal of Rheumatology
Volume8
Issue numberSuppl. 7
StatePublished - 1981
Externally publishedYes

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Penicillamine
Collagen Type II
Arthritis
Joints
X-Rays
Inflammation
Antibodies
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology
  • Rheumatology
  • Medicine(all)

Cite this

Kerwar, S. S., Sloboda, A. E., Birnbaum, J. E., & Oronsky, A. L. (1981). Studies on the effect of D-penicillamine on type II collagen-induced polyarthritis. Journal of Rheumatology, 8(Suppl. 7), 84-89.

Studies on the effect of D-penicillamine on type II collagen-induced polyarthritis. / Kerwar, S. S.; Sloboda, A. E.; Birnbaum, J. E.; Oronsky, A. L.

In: Journal of Rheumatology, Vol. 8, No. Suppl. 7, 1981, p. 84-89.

Research output: Contribution to journalArticle

Kerwar, SS, Sloboda, AE, Birnbaum, JE & Oronsky, AL 1981, 'Studies on the effect of D-penicillamine on type II collagen-induced polyarthritis', Journal of Rheumatology, vol. 8, no. Suppl. 7, pp. 84-89.
Kerwar SS, Sloboda AE, Birnbaum JE, Oronsky AL. Studies on the effect of D-penicillamine on type II collagen-induced polyarthritis. Journal of Rheumatology. 1981;8(Suppl. 7):84-89.
Kerwar, S. S. ; Sloboda, A. E. ; Birnbaum, J. E. ; Oronsky, A. L. / Studies on the effect of D-penicillamine on type II collagen-induced polyarthritis. In: Journal of Rheumatology. 1981 ; Vol. 8, No. Suppl. 7. pp. 84-89.
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