Studies on the application of the relative-dose-response test for assessing vitamin A status in older adults

J. Bulux, E. Carranza, C. Castaneda, N. W. Solomons, L. J. Sokoll, F. D. Morrow, R. M. Russell

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the time course and the reproducibility of the relative- dose-response (RDR) test for assessing vitamin A status in older adults. The maximum plasma retinol response to 480 retinol equivalents (RE) of retinyl palmitate in abnormal responses was at 6 or 7 h after dosing compared with the 5-h sampling interval recommended by others for younger adults and children. With respect to reproducibility, the diagnostic concordance of two RDR tests at 7-d intervals in 14 elders was 71%. In 29% of tests, one test was abnormal and the other normal. Linear regression of the two RDR values in these 14 subjects gave a correlation coefficient of -0.08. We conclude that the procedure for the RDR should be modified when applied to persons > 60 y of age, and that multiple repetitions of the test are needed to provide a stable indication of vitamin A stores in an elderly individual.

Original languageEnglish (US)
Pages (from-to)543-547
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume56
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • Aging
  • relative dose response
  • retinol
  • vitamin A

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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