Studies on the antibacterial potentiality of isoflavones

Sujata G. Dastidar, A. Manna, K. Asok Kumar, Kaushiki Mazumdar, N. K. Dutta, A. N. Chakrabarty, Noboru Motohashi, Yoshiaki Shirataki

Research output: Contribution to journalArticlepeer-review

Abstract

The isoflavonoid compounds 'YS11-YS21' were screened for possible antimicrobial property against 12 known Gram-positive and Gram-negative sensitive bacteria. YS11 and YS16 failed to show antimicrobial activity and YS12, 13, 14, 15, 17, 18 and 20 had moderate antimicrobial action. Compounds YS19 and YS21 showed pronounced antimicrobial property. YS19 and YS21 were then tested in vitro against 214 strains of bacteria from one Gram-positive and six Gram-negative genera. The minimum inhibitory concentration (MIC) of YS19 and YS21 was determined by agar dilution method and ranged from 25 to 200mg/l in most strains. At concentrations of 30 and 60μg/mouse these compounds offered significant protection to mice challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella Typhimurium.

Original languageEnglish (US)
Pages (from-to)99-102
Number of pages4
JournalInternational Journal of Antimicrobial Agents
Volume23
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

Keywords

  • Antimicrobial activity
  • Isoflavonoids
  • Non-antibiotics

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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