Studies on the antibacterial potentiality of isoflavones

Sujata G. Dastidar; A. Manna; K. Asok Kumar; Kaushiki Mazumdar; N. K. Dutta; A. N. Chakrabarty; Noboru Motohashi; Yoshiaki Shirataki

doi:10.1016/j.ijantimicag.2003.06.003

Studies on the antibacterial potentiality of isoflavones

Sujata G. Dastidar, A. Manna, K. Asok Kumar, Kaushiki Mazumdar, N. K. Dutta, A. N. Chakrabarty, Noboru Motohashi, Yoshiaki Shirataki

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The isoflavonoid compounds 'YS11-YS21' were screened for possible antimicrobial property against 12 known Gram-positive and Gram-negative sensitive bacteria. YS11 and YS16 failed to show antimicrobial activity and YS12, 13, 14, 15, 17, 18 and 20 had moderate antimicrobial action. Compounds YS19 and YS21 showed pronounced antimicrobial property. YS19 and YS21 were then tested in vitro against 214 strains of bacteria from one Gram-positive and six Gram-negative genera. The minimum inhibitory concentration (MIC) of YS19 and YS21 was determined by agar dilution method and ranged from 25 to 200mg/l in most strains. At concentrations of 30 and 60μg/mouse these compounds offered significant protection to mice challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella Typhimurium.

Original language	English (US)
Pages (from-to)	99-102
Number of pages	4
Journal	International Journal of Antimicrobial Agents
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.ijantimicag.2003.06.003
State	Published - Jan 2004
Externally published	Yes

Keywords

Antimicrobial activity
Isoflavonoids
Non-antibiotics

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

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10.1016/j.ijantimicag.2003.06.003

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title = "Studies on the antibacterial potentiality of isoflavones",

abstract = "The isoflavonoid compounds 'YS11-YS21' were screened for possible antimicrobial property against 12 known Gram-positive and Gram-negative sensitive bacteria. YS11 and YS16 failed to show antimicrobial activity and YS12, 13, 14, 15, 17, 18 and 20 had moderate antimicrobial action. Compounds YS19 and YS21 showed pronounced antimicrobial property. YS19 and YS21 were then tested in vitro against 214 strains of bacteria from one Gram-positive and six Gram-negative genera. The minimum inhibitory concentration (MIC) of YS19 and YS21 was determined by agar dilution method and ranged from 25 to 200mg/l in most strains. At concentrations of 30 and 60μg/mouse these compounds offered significant protection to mice challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella Typhimurium.",

keywords = "Antimicrobial activity, Isoflavonoids, Non-antibiotics",

author = "Dastidar, {Sujata G.} and A. Manna and Kumar, {K. Asok} and Kaushiki Mazumdar and Dutta, {N. K.} and Chakrabarty, {A. N.} and Noboru Motohashi and Yoshiaki Shirataki",

note = "Funding Information: HPLC separation of this study was supported in part by a Grant from the Apparatus Fund 2002 of Josai University. ",

year = "2004",

month = jan,

doi = "10.1016/j.ijantimicag.2003.06.003",

language = "English (US)",

volume = "23",

pages = "99--102",

journal = "International Journal of Antimicrobial Agents",

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AU - Dastidar, Sujata G.

AU - Manna, A.

AU - Kumar, K. Asok

AU - Mazumdar, Kaushiki

AU - Dutta, N. K.

AU - Chakrabarty, A. N.

AU - Motohashi, Noboru

AU - Shirataki, Yoshiaki

N1 - Funding Information: HPLC separation of this study was supported in part by a Grant from the Apparatus Fund 2002 of Josai University.

PY - 2004/1

Y1 - 2004/1

N2 - The isoflavonoid compounds 'YS11-YS21' were screened for possible antimicrobial property against 12 known Gram-positive and Gram-negative sensitive bacteria. YS11 and YS16 failed to show antimicrobial activity and YS12, 13, 14, 15, 17, 18 and 20 had moderate antimicrobial action. Compounds YS19 and YS21 showed pronounced antimicrobial property. YS19 and YS21 were then tested in vitro against 214 strains of bacteria from one Gram-positive and six Gram-negative genera. The minimum inhibitory concentration (MIC) of YS19 and YS21 was determined by agar dilution method and ranged from 25 to 200mg/l in most strains. At concentrations of 30 and 60μg/mouse these compounds offered significant protection to mice challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella Typhimurium.

AB - The isoflavonoid compounds 'YS11-YS21' were screened for possible antimicrobial property against 12 known Gram-positive and Gram-negative sensitive bacteria. YS11 and YS16 failed to show antimicrobial activity and YS12, 13, 14, 15, 17, 18 and 20 had moderate antimicrobial action. Compounds YS19 and YS21 showed pronounced antimicrobial property. YS19 and YS21 were then tested in vitro against 214 strains of bacteria from one Gram-positive and six Gram-negative genera. The minimum inhibitory concentration (MIC) of YS19 and YS21 was determined by agar dilution method and ranged from 25 to 200mg/l in most strains. At concentrations of 30 and 60μg/mouse these compounds offered significant protection to mice challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella Typhimurium.

KW - Antimicrobial activity

KW - Isoflavonoids

KW - Non-antibiotics

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AN - SCOPUS:0347090623

SN - 0924-8579

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JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 1

ER -

Studies on the antibacterial potentiality of isoflavones

Abstract

Keywords

ASJC Scopus subject areas

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