Studies on the allergy-like food poisoning associated with putrefaction of marine products: III. Physiological and pharmacological action of “saurine”, a vagusstimulant of unknown structure recently isolated by the authors, and its characteristics in developing allergy-like symptoms

Toshiharu Kawabata, Kimishige Ishizaka, Toshiyuki Miura

Research output: Contribution to journalArticle

Abstract

The physiological and pharmacological actions of “saurine” was examined by means of the contraction of intestine of guinea pigs and mice by Magnus method, skin reaction in rabbits, shock symptoms in guinea pigs and antagonism against anti-allergic drugs were tested. The conclusions drawn are as follows: 1. “Saurine” is different from acetylcholine. 2. This poison has merely an additive effect to that of histamine. 3. The skin reaction in rabbits and the shock symptoms in guinea pigs caused by the injection of this substance are similar to those caused by histamine. 4. As for the antagonism between this substance and anti-allergic drugs tested on contraction of intestine, the effect of the drugs was proportional to their antihistaminic activity. 5. These findings mentioned above may suggest that this substance is resembling to histamine in its action.

Original languageEnglish (US)
Pages (from-to)521-528
Number of pages8
JournalJapanese Journal of Medical Science and Biology
Volume8
Issue number6
DOIs
StatePublished - Jan 1 1955

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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