TY - JOUR
T1 - Studies on the allergy-like food poisoning associated with putrefaction of marine products
T2 - III. Physiological and pharmacological action of “saurine”, a vagusstimulant of unknown structure recently isolated by the authors, and its characteristics in developing allergy-like symptoms
AU - Kawabata, Toshiharu
AU - Ishizaka, Kimishige
AU - Miura, Toshiyuki
PY - 1955/1/1
Y1 - 1955/1/1
N2 - The physiological and pharmacological actions of “saurine” was examined by means of the contraction of intestine of guinea pigs and mice by Magnus method, skin reaction in rabbits, shock symptoms in guinea pigs and antagonism against anti-allergic drugs were tested. The conclusions drawn are as follows: 1. “Saurine” is different from acetylcholine. 2. This poison has merely an additive effect to that of histamine. 3. The skin reaction in rabbits and the shock symptoms in guinea pigs caused by the injection of this substance are similar to those caused by histamine. 4. As for the antagonism between this substance and anti-allergic drugs tested on contraction of intestine, the effect of the drugs was proportional to their antihistaminic activity. 5. These findings mentioned above may suggest that this substance is resembling to histamine in its action.
AB - The physiological and pharmacological actions of “saurine” was examined by means of the contraction of intestine of guinea pigs and mice by Magnus method, skin reaction in rabbits, shock symptoms in guinea pigs and antagonism against anti-allergic drugs were tested. The conclusions drawn are as follows: 1. “Saurine” is different from acetylcholine. 2. This poison has merely an additive effect to that of histamine. 3. The skin reaction in rabbits and the shock symptoms in guinea pigs caused by the injection of this substance are similar to those caused by histamine. 4. As for the antagonism between this substance and anti-allergic drugs tested on contraction of intestine, the effect of the drugs was proportional to their antihistaminic activity. 5. These findings mentioned above may suggest that this substance is resembling to histamine in its action.
UR - http://www.scopus.com/inward/record.url?scp=84890256275&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890256275&partnerID=8YFLogxK
U2 - 10.7883/yoken1952.8.521
DO - 10.7883/yoken1952.8.521
M3 - Article
C2 - 13345545
AN - SCOPUS:84890256275
SN - 0021-5112
VL - 8
SP - 521
EP - 528
JO - Japanese Journal of Medical Science and Biology
JF - Japanese Journal of Medical Science and Biology
IS - 6
ER -