We have found that cadaver renal transplant recipients who develop cytomegalovirus (CMV) diseae produce IgM immune complexes as measured by polyethyleneglycol (PEG) precipitation 1. The IgM immune complexes initially increase when IgM antibodies to CMV are first detected and they persist for one to six months. In recent studies2, the PEG precipitates from 15 of 23 patients with CMV disease were shown to contain IgM lymphocytotoxins that lysed T as well as B lymphocytes at 22°C. In contrast, sera from eight of 15 control patients undergoing acute graft rejection without concomitant CMV disease and from each of 15 hyperimmune patients contained primarily IgG lymphocytotoxins that were not precipitated by 3.5% PEG. Nine patients with CMV disease had IgM rheumatoid factors (RFs) v zero of 15 control patients. Both IgM lymphocytotoxins and RFs were associated with symptoms of renal dysfunction (increases in creatinine or proteinuria). Presently, we are better characterizing these 'nonspecific' antibodies to elucidate their possible pathogenic significance in CMV disease.
|Original language||English (US)|
|Number of pages||2|
|Issue number||1 I|
|State||Published - 1985|
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