Glucuronyl transferase activity in rats chronically treated with morphine is decreased whereas that in rats chronically treated with phenol is unchanged when the enzymic activity is compared with that in control rats. The depressed enzymic activity in rats treated with morphine is apparent regardless of whether morphine or phenol is used as the substrate in assaying the activity. The activity of uridine diphosphate (UDP)-glucose dehydrogenase remains unaltered in the experimental animals. The glucuronyl transferase reaction in rats chronically treated with morphine becomes rate-limiting in conjugating foreign substances in the body.
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