Studies on a leukocyte elastase inhibitor present in the culture medium of inflamed synovial tissue

Mary E. Englert; M. Jane Landes; Jay E. Birnbaum; Arnold L. Oronsky; S. S. Kerwar

doi:10.1016/0006-291X(80)91242-5

Studies on a leukocyte elastase inhibitor present in the culture medium of inflamed synovial tissue

Mary E. Englert, M. Jane Landes, Jay E. Birnbaum, Arnold L. Oronsky, S. S. Kerwar

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The spent medium of cultured inflamed synovial tissue contains a potent inhibitor of leukocyte elastase. This leukocyte elastase inhibitor has no effect on leukocyte cathepsin G and pancreatic elastase is only marginally affected. The inhibitor is a glycoprotein, stable to heat, acid and reductive alkylation. Pretreatment of the inhibitor with either trypsin or chymotrypsin results in its inactivation.

Original language	English (US)
Pages (from-to)	498-505
Number of pages	8
Journal	Topics in Catalysis
Volume	96
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(80)91242-5
State	Published - Jan 1 1980

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Biophysics
Molecular Biology

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10.1016/0006-291X(80)91242-5

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abstract = "The spent medium of cultured inflamed synovial tissue contains a potent inhibitor of leukocyte elastase. This leukocyte elastase inhibitor has no effect on leukocyte cathepsin G and pancreatic elastase is only marginally affected. The inhibitor is a glycoprotein, stable to heat, acid and reductive alkylation. Pretreatment of the inhibitor with either trypsin or chymotrypsin results in its inactivation.",

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AU - Kerwar, S. S.

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N2 - The spent medium of cultured inflamed synovial tissue contains a potent inhibitor of leukocyte elastase. This leukocyte elastase inhibitor has no effect on leukocyte cathepsin G and pancreatic elastase is only marginally affected. The inhibitor is a glycoprotein, stable to heat, acid and reductive alkylation. Pretreatment of the inhibitor with either trypsin or chymotrypsin results in its inactivation.

AB - The spent medium of cultured inflamed synovial tissue contains a potent inhibitor of leukocyte elastase. This leukocyte elastase inhibitor has no effect on leukocyte cathepsin G and pancreatic elastase is only marginally affected. The inhibitor is a glycoprotein, stable to heat, acid and reductive alkylation. Pretreatment of the inhibitor with either trypsin or chymotrypsin results in its inactivation.

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Studies on a leukocyte elastase inhibitor present in the culture medium of inflamed synovial tissue

Abstract

ASJC Scopus subject areas

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