Studies on a leukocyte elastase inhibitor present in the culture medium of inflamed synovial tissue

Mary E. Englert, M. Jane Landes, Jay E. Birnbaum, Arnold L. Oronsky, S. S. Kerwar

Research output: Contribution to journalArticlepeer-review

Abstract

The spent medium of cultured inflamed synovial tissue contains a potent inhibitor of leukocyte elastase. This leukocyte elastase inhibitor has no effect on leukocyte cathepsin G and pancreatic elastase is only marginally affected. The inhibitor is a glycoprotein, stable to heat, acid and reductive alkylation. Pretreatment of the inhibitor with either trypsin or chymotrypsin results in its inactivation.

Original languageEnglish (US)
Pages (from-to)498-505
Number of pages8
JournalTopics in Catalysis
Volume96
Issue number1
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Biophysics
  • Molecular Biology

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