Studies on β-adrenoceptors of purified mast cells from guinea-pig lung

Bradley J. Undem, Frank M. Graziano, Carl K. Buckner

Research output: Contribution to journalArticlepeer-review

Abstract

Ovalbumin-induced histamine release from passively sensitized monodispersed cells (2-4% mast cells) or purified mast cells (50-78%) from guinea-pig lung was inhibited by isoproterenol and sulfonterol and their relative potencies or maximum responses were similar in both cases. The apparent dissociation constant for butoxamine was also independent of mast cell purity. The results indicate that β-adrenoceptors mediating histamine release inhibition from lung are localized to mast cells and act independently of other cell types.

Original languageEnglish (US)
Pages (from-to)413-416
Number of pages4
JournalEuropean Journal of Pharmacology
Volume109
Issue number3
DOIs
StatePublished - Mar 12 1985
Externally publishedYes

Keywords

  • Butoxamine
  • Guinea-pig lung
  • Isoproterenol
  • Monodispersed lung cells
  • Purified lung mast cells
  • Sulfonterol

ASJC Scopus subject areas

  • Pharmacology

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