Studies on β-adrenoceptors of purified mast cells from guinea-pig lung

Bradley J. Undem; Frank M. Graziano; Carl K. Buckner

doi:10.1016/0014-2999(85)90405-4

Studies on β-adrenoceptors of purified mast cells from guinea-pig lung

Bradley J. Undem, Frank M. Graziano, Carl K. Buckner

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Ovalbumin-induced histamine release from passively sensitized monodispersed cells (2-4% mast cells) or purified mast cells (50-78%) from guinea-pig lung was inhibited by isoproterenol and sulfonterol and their relative potencies or maximum responses were similar in both cases. The apparent dissociation constant for butoxamine was also independent of mast cell purity. The results indicate that β-adrenoceptors mediating histamine release inhibition from lung are localized to mast cells and act independently of other cell types.

Original language	English (US)
Pages (from-to)	413-416
Number of pages	4
Journal	European Journal of Pharmacology
Volume	109
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(85)90405-4
State	Published - Mar 12 1985
Externally published	Yes

Keywords

Butoxamine
Guinea-pig lung
Isoproterenol
Monodispersed lung cells
Purified lung mast cells
Sulfonterol

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(85)90405-4

Cite this

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title = "Studies on β-adrenoceptors of purified mast cells from guinea-pig lung",

abstract = "Ovalbumin-induced histamine release from passively sensitized monodispersed cells (2-4% mast cells) or purified mast cells (50-78%) from guinea-pig lung was inhibited by isoproterenol and sulfonterol and their relative potencies or maximum responses were similar in both cases. The apparent dissociation constant for butoxamine was also independent of mast cell purity. The results indicate that β-adrenoceptors mediating histamine release inhibition from lung are localized to mast cells and act independently of other cell types.",

keywords = "Butoxamine, Guinea-pig lung, Isoproterenol, Monodispersed lung cells, Purified lung mast cells, Sulfonterol",

author = "Undem, {Bradley J.} and Graziano, {Frank M.} and Buckner, {Carl K.}",

note = "Funding Information: 1 This work was supported by National Institutes of Health Grant HL28585. To whom all correspondence should be addressed: School of Pharmacy, University of Wisconsin, 425 N. Charter St., Madison, WI 53706, U.S.A.",

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doi = "10.1016/0014-2999(85)90405-4",

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T1 - Studies on β-adrenoceptors of purified mast cells from guinea-pig lung

AU - Undem, Bradley J.

AU - Graziano, Frank M.

AU - Buckner, Carl K.

N1 - Funding Information: 1 This work was supported by National Institutes of Health Grant HL28585. To whom all correspondence should be addressed: School of Pharmacy, University of Wisconsin, 425 N. Charter St., Madison, WI 53706, U.S.A.

PY - 1985/3/12

Y1 - 1985/3/12

N2 - Ovalbumin-induced histamine release from passively sensitized monodispersed cells (2-4% mast cells) or purified mast cells (50-78%) from guinea-pig lung was inhibited by isoproterenol and sulfonterol and their relative potencies or maximum responses were similar in both cases. The apparent dissociation constant for butoxamine was also independent of mast cell purity. The results indicate that β-adrenoceptors mediating histamine release inhibition from lung are localized to mast cells and act independently of other cell types.

AB - Ovalbumin-induced histamine release from passively sensitized monodispersed cells (2-4% mast cells) or purified mast cells (50-78%) from guinea-pig lung was inhibited by isoproterenol and sulfonterol and their relative potencies or maximum responses were similar in both cases. The apparent dissociation constant for butoxamine was also independent of mast cell purity. The results indicate that β-adrenoceptors mediating histamine release inhibition from lung are localized to mast cells and act independently of other cell types.

KW - Butoxamine

KW - Guinea-pig lung

KW - Isoproterenol

KW - Monodispersed lung cells

KW - Purified lung mast cells

KW - Sulfonterol

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Studies on β-adrenoceptors of purified mast cells from guinea-pig lung

Abstract

Keywords

ASJC Scopus subject areas

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