Abstract
Previous studies of human triploidy have implicated the autosomes in the regulation of activity of X-linked genes. To determine if the influence of the extra autosomal set in triploids was attributable to a specific autosomal gene, we examined the pattern of DNA replication in females trisomic for 18 of the possible 22 autosomal trisomies. We find no evidence that a single gene or chromosome in triplicate can effect X-chromosome replication or activity. Our results suggest either than more than one locus in triplicate is required to maintain the activity of two X chromosomes, or that the influence of the extra autosomal set in enabling the activity of more than a single X chromosome is mediated indirectly, perhaps through the agency of increased nuclear size or changes in the cell cycle.
Original language | English (US) |
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Pages (from-to) | 75-77 |
Number of pages | 3 |
Journal | Cytogenetics and cell genetics |
Volume | 50 |
Issue number | 2-3 |
DOIs | |
State | Published - 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Cell Biology