Studies of X-chromosome inactivation in trisomies

P. A. Jacobs, Barbara R Migeon

Research output: Contribution to journalArticle

Abstract

Previous studies of human triploidy have implicated the autosomes in the regulation of activity of X-linked genes. To determine if the influence of the extra autosomal set in triploids was attributable to a specific autosomal gene, we examined the pattern of DNA replication in females trisomic for 18 of the possible 22 autosomal trisomies. We find no evidence that a single gene or chromosome in triplicate can effect X-chromosome replication or activity. Our results suggest either than more than one locus in triplicate is required to maintain the activity of two X chromosomes, or that the influence of the extra autosomal set in enabling the activity of more than a single X chromosome is mediated indirectly, perhaps through the agency of increased nuclear size or changes in the cell cycle.

Original languageEnglish (US)
Pages (from-to)75-77
Number of pages3
JournalCytogenetics and Cell Genetics
Volume50
Issue number2-3
StatePublished - 1989
Externally publishedYes

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X Chromosome Inactivation
Trisomy
X Chromosome
Triploidy
X-Linked Genes
DNA Replication
Genes
Cell Cycle
Chromosomes

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

Studies of X-chromosome inactivation in trisomies. / Jacobs, P. A.; Migeon, Barbara R.

In: Cytogenetics and Cell Genetics, Vol. 50, No. 2-3, 1989, p. 75-77.

Research output: Contribution to journalArticle

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