Studies of prototype live hepatitis a virus vaccines in primate models

Ruth A Karron, R. Daemer, John R Ticehurst, E. D’Hondt, H. Popper, K. Mihalik, J. Phillips, S. Feinstone, R. H. Purcell, R. A. Karron

Research output: Contribution to journalArticle

Abstract

We have prepared two prototype live hepatitis A virus (HAV) vaccines by serial passage of the HM-175 strain of HAV in African green monkey kidney cells. Passage 21 (P-21) HM-175 virus shows evidence of attentuation for chimpanzees but not for marmosets; passage 32 (P-32) HM-175 virus shows evidence of attenuation for both species. Animals that received P-32 HAV had fewer elevations in levels of liver enzyme activity and evidence of less virus replication in the liver and excretion of virus in stool than did those that received wild-type virus. The P-21 and P-32 viruses were highly immunogenic in both species. The information provided by this study will aid in the development of a live HAV vaccine.

Original languageEnglish (US)
Pages (from-to)338-345
Number of pages8
JournalJournal of Infectious Diseases
Volume157
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

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Hepatitis Viruses
Hepatitis A virus
Primates
Vaccines
Viruses
Hepatitis A Vaccines
Serial Passage
Cercopithecus aethiops
Callithrix
Pan troglodytes
Liver
Virus Replication
Kidney
Enzymes

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Studies of prototype live hepatitis a virus vaccines in primate models. / Karron, Ruth A; Daemer, R.; Ticehurst, John R; D’Hondt, E.; Popper, H.; Mihalik, K.; Phillips, J.; Feinstone, S.; Purcell, R. H.; Karron, R. A.

In: Journal of Infectious Diseases, Vol. 157, No. 2, 1988, p. 338-345.

Research output: Contribution to journalArticle

Karron, RA, Daemer, R, Ticehurst, JR, D’Hondt, E, Popper, H, Mihalik, K, Phillips, J, Feinstone, S, Purcell, RH & Karron, RA 1988, 'Studies of prototype live hepatitis a virus vaccines in primate models', Journal of Infectious Diseases, vol. 157, no. 2, pp. 338-345. https://doi.org/10.1093/infdis/157.2.338
Karron, Ruth A ; Daemer, R. ; Ticehurst, John R ; D’Hondt, E. ; Popper, H. ; Mihalik, K. ; Phillips, J. ; Feinstone, S. ; Purcell, R. H. ; Karron, R. A. / Studies of prototype live hepatitis a virus vaccines in primate models. In: Journal of Infectious Diseases. 1988 ; Vol. 157, No. 2. pp. 338-345.
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