Studies of pancreatic nodule induction and DNA damage by D-azaserine

Joanne Zurlo, Daniel S. Longnecker, David A. Cooney, Elna T. Kuhlmann, Thomas J. Curphey

Research output: Contribution to journalArticle

Abstract

The ability of the D-isomer of azaserine to induce atypical acinar cell nodules (AACN) in pancreas and to cause DNA damage in pancreas and liver was evaluated. Rats were injected with equivalent doses of D- or L-azaserine and numbers of AACN were counted after 4 months. DNA damage in pancreas and liver of rats treated in vivo, and in pancreatic acinar cells treated in vitro with D- or L-azaserine was determined by alkaline elution. Results show that D-azaserine does not significantly induced AACN in pancreas, nor does it cause extensive DNA damage in comparison with L-azaserine, suggesting that the differential effect of the 2 isomers is related to stereospecificity in either transport or metabolism.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalCancer Letters
Volume12
Issue number1-2
DOIs
StatePublished - Mar 1981

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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