Abstract
The ability of the D-isomer of azaserine to induce atypical acinar cell nodules (AACN) in pancreas and to cause DNA damage in pancreas and liver was evaluated. Rats were injected with equivalent doses of D- or L-azaserine and numbers of AACN were counted after 4 months. DNA damage in pancreas and liver of rats treated in vivo, and in pancreatic acinar cells treated in vitro with D- or L-azaserine was determined by alkaline elution. Results show that D-azaserine does not significantly induced AACN in pancreas, nor does it cause extensive DNA damage in comparison with L-azaserine, suggesting that the differential effect of the 2 isomers is related to stereospecificity in either transport or metabolism.
Original language | English (US) |
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Pages (from-to) | 75-80 |
Number of pages | 6 |
Journal | Cancer Letters |
Volume | 12 |
Issue number | 1-2 |
DOIs | |
State | Published - Mar 1981 |
ASJC Scopus subject areas
- Oncology
- Cancer Research