Three types of papovaviruses (JC, BK, and SV40) have been isolated from man. All three are oncogenic in hamsters, cause frequent infection of man, and share a common T antigen. Augmentation of the expression of T antigen by in vitro cultivation of SV40-induced tumors of hamsters suggested that growing human brain tumors in vitro might provide an effective screening technique for the SV40 virus. In a series of human brain tumors examined in cryostat sections and in tissue culture, T antigen could not be demonstrated, suggesting that by this immunofluorescent technique SV40 was not implicated in the etiology of these tumors.
|Original language||English (US)|
|Number of pages||5|
|Journal||Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques|
|State||Published - May 1976|
ASJC Scopus subject areas
- Clinical Neurology