Studies of Human Papovavirus Tumor Antigen in Experimental and Human Cerebral Neoplasms

L. E. Becker, O. Narayan, R. T. Johnson

Research output: Contribution to journalArticlepeer-review

Abstract

Three types of papovaviruses (JC, BK, and SV40) have been isolated from man. All three are oncogenic in hamsters, cause frequent infection of man, and share a common T antigen. Augmentation of the expression of T antigen by in vitro cultivation of SV40-induced tumors of hamsters suggested that growing human brain tumors in vitro might provide an effective screening technique for the SV40 virus. In a series of human brain tumors examined in cryostat sections and in tissue culture, T antigen could not be demonstrated, suggesting that by this immunofluorescent technique SV40 was not implicated in the etiology of these tumors.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Volume3
Issue number2
DOIs
StatePublished - May 1976

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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