TY - JOUR
T1 - Studies of Human Papovavirus Tumor Antigen in Experimental and Human Cerebral Neoplasms
AU - Becker, L. E.
AU - Narayan, O.
AU - Johnson, R. T.
PY - 1976/5
Y1 - 1976/5
N2 - Three types of papovaviruses (JC, BK, and SV40) have been isolated from man. All three are oncogenic in hamsters, cause frequent infection of man, and share a common T antigen. Augmentation of the expression of T antigen by in vitro cultivation of SV40-induced tumors of hamsters suggested that growing human brain tumors in vitro might provide an effective screening technique for the SV40 virus. In a series of human brain tumors examined in cryostat sections and in tissue culture, T antigen could not be demonstrated, suggesting that by this immunofluorescent technique SV40 was not implicated in the etiology of these tumors.
AB - Three types of papovaviruses (JC, BK, and SV40) have been isolated from man. All three are oncogenic in hamsters, cause frequent infection of man, and share a common T antigen. Augmentation of the expression of T antigen by in vitro cultivation of SV40-induced tumors of hamsters suggested that growing human brain tumors in vitro might provide an effective screening technique for the SV40 virus. In a series of human brain tumors examined in cryostat sections and in tissue culture, T antigen could not be demonstrated, suggesting that by this immunofluorescent technique SV40 was not implicated in the etiology of these tumors.
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U2 - 10.1017/S0317167100025853
DO - 10.1017/S0317167100025853
M3 - Article
C2 - 178420
AN - SCOPUS:0017112227
SN - 0317-1671
VL - 3
SP - 105
EP - 109
JO - Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
JF - Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
IS - 2
ER -