Studies of HLA antigen frequencies, IgE levels, and specific allergic sensitivities in patients having ragweed hayfever, with and without asthma

C. A. Bruce, W. B. Bias, Philip S. Norman, L. M. Lightenstein, D. G. Marsh

Research output: Contribution to journalArticle

Abstract

In order to study genetic and immunological features which might be important in the pathogenesis of asthma, forty one ragweed allergic seasonal asthmatics were first matched with forty one ragweed allergic nonasthmatics on the basis of similar total IgE levels. No significant differences were observed in their sensitivity to ragweed antigen E (measured by histamine release), or in their skin response to ragweed antigens E, Ra3 and Ra5. An increased frequency of HLA B5 was observed in nonasthmatics as compared to asthmatics (P = 0.03). Although frequencies of HLA A1 and B8 were also elevated in nonasthmatics and HLA B40 in asthmatics, these differences were not significant. The forty one asthmatic patients were then paired with forty one nonasthmatics on the basis of leucocyte sensitivity to ragweed antigen E. Similar HLA differences were found which were non sigificant. No significant difference in total IgE levels were found between the two groups. Whereas no differences in IgE synthesis or antigen sensitivity was found in the two populations, the frequency of HLA antigens needs further study in larger groups.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalClinical and Experimental Immunology
Volume25
Issue number1
StatePublished - 1976

Fingerprint

Ambrosia
Seasonal Allergic Rhinitis
HLA Antigens
Immunoglobulin E
Asthma
HLA-B40 Antigen
HLA-A1 Antigen
HLA-B8 Antigen
Histamine Release
Leukocytes
Antigens
Skin
Population
Ambrosia artemisiifolia Amb a I protein

ASJC Scopus subject areas

  • Immunology

Cite this

Studies of HLA antigen frequencies, IgE levels, and specific allergic sensitivities in patients having ragweed hayfever, with and without asthma. / Bruce, C. A.; Bias, W. B.; Norman, Philip S.; Lightenstein, L. M.; Marsh, D. G.

In: Clinical and Experimental Immunology, Vol. 25, No. 1, 1976, p. 67-72.

Research output: Contribution to journalArticle

@article{26a48e63e765446ea07286889bc0b156,
title = "Studies of HLA antigen frequencies, IgE levels, and specific allergic sensitivities in patients having ragweed hayfever, with and without asthma",
abstract = "In order to study genetic and immunological features which might be important in the pathogenesis of asthma, forty one ragweed allergic seasonal asthmatics were first matched with forty one ragweed allergic nonasthmatics on the basis of similar total IgE levels. No significant differences were observed in their sensitivity to ragweed antigen E (measured by histamine release), or in their skin response to ragweed antigens E, Ra3 and Ra5. An increased frequency of HLA B5 was observed in nonasthmatics as compared to asthmatics (P = 0.03). Although frequencies of HLA A1 and B8 were also elevated in nonasthmatics and HLA B40 in asthmatics, these differences were not significant. The forty one asthmatic patients were then paired with forty one nonasthmatics on the basis of leucocyte sensitivity to ragweed antigen E. Similar HLA differences were found which were non sigificant. No significant difference in total IgE levels were found between the two groups. Whereas no differences in IgE synthesis or antigen sensitivity was found in the two populations, the frequency of HLA antigens needs further study in larger groups.",
author = "Bruce, {C. A.} and Bias, {W. B.} and Norman, {Philip S.} and Lightenstein, {L. M.} and Marsh, {D. G.}",
year = "1976",
language = "English (US)",
volume = "25",
pages = "67--72",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Studies of HLA antigen frequencies, IgE levels, and specific allergic sensitivities in patients having ragweed hayfever, with and without asthma

AU - Bruce, C. A.

AU - Bias, W. B.

AU - Norman, Philip S.

AU - Lightenstein, L. M.

AU - Marsh, D. G.

PY - 1976

Y1 - 1976

N2 - In order to study genetic and immunological features which might be important in the pathogenesis of asthma, forty one ragweed allergic seasonal asthmatics were first matched with forty one ragweed allergic nonasthmatics on the basis of similar total IgE levels. No significant differences were observed in their sensitivity to ragweed antigen E (measured by histamine release), or in their skin response to ragweed antigens E, Ra3 and Ra5. An increased frequency of HLA B5 was observed in nonasthmatics as compared to asthmatics (P = 0.03). Although frequencies of HLA A1 and B8 were also elevated in nonasthmatics and HLA B40 in asthmatics, these differences were not significant. The forty one asthmatic patients were then paired with forty one nonasthmatics on the basis of leucocyte sensitivity to ragweed antigen E. Similar HLA differences were found which were non sigificant. No significant difference in total IgE levels were found between the two groups. Whereas no differences in IgE synthesis or antigen sensitivity was found in the two populations, the frequency of HLA antigens needs further study in larger groups.

AB - In order to study genetic and immunological features which might be important in the pathogenesis of asthma, forty one ragweed allergic seasonal asthmatics were first matched with forty one ragweed allergic nonasthmatics on the basis of similar total IgE levels. No significant differences were observed in their sensitivity to ragweed antigen E (measured by histamine release), or in their skin response to ragweed antigens E, Ra3 and Ra5. An increased frequency of HLA B5 was observed in nonasthmatics as compared to asthmatics (P = 0.03). Although frequencies of HLA A1 and B8 were also elevated in nonasthmatics and HLA B40 in asthmatics, these differences were not significant. The forty one asthmatic patients were then paired with forty one nonasthmatics on the basis of leucocyte sensitivity to ragweed antigen E. Similar HLA differences were found which were non sigificant. No significant difference in total IgE levels were found between the two groups. Whereas no differences in IgE synthesis or antigen sensitivity was found in the two populations, the frequency of HLA antigens needs further study in larger groups.

UR - http://www.scopus.com/inward/record.url?scp=0017070744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017070744&partnerID=8YFLogxK

M3 - Article

C2 - 991452

AN - SCOPUS:0017070744

VL - 25

SP - 67

EP - 72

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 1

ER -