Structured outlier detection in neuroimaging studies with minimal convex polytopes

Erdem Varol, Aristeidis Sotiras, Christos Davatzikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Computer assisted imaging aims to characterize disease processes by contrasting healthy and pathological populations. The sensitivity of these analyses is hindered by the variability in the neuroanatomy of the normal population. To alleviate this shortcoming,it is necessary to define a normative range of controls. Moreover,elucidating the structure in outliers may be important in understanding diverging individuals and characterizing prodromal disease states. To address these issues,we propose a novel geometric concept called minimal convex polytope (MCP). The proposed approach is used to simultaneously capture high probability regions in datasets consisting of normal subjects,and delineate outliers,thus characterizing the main directions of deviation from the normative range. We validated our method using simulated datasets before applying it to an imaging study of elderly subjects consisting of 177 controls,123 Alzheimer’s disease (AD) and 285 mild cognitive impairment (MCI) patients. We show that cerebellar degeneration is a major type of deviation among the controls. Furthermore,our findings suggest that a subset of AD patients may be following an accelerated type of deviation that is observed among the normal population.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2016 - 19th International Conference, Proceedings
EditorsGozde Unal, Mert R. Sabuncu, William Wells, Sebastian Ourselin, Leo Joskowicz
PublisherSpringer Verlag
Pages300-307
Number of pages8
ISBN (Print)9783319467191
DOIs
StatePublished - 2016
Event1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016 - Athens, Greece
Duration: Oct 21 2016Oct 21 2016

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9900 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016
CountryGreece
CityAthens
Period10/21/1610/21/16

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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