The pores of voltage-gated cation channels are formed by four intramembrane segments that impart selectivity and conductance. Remarkably little is known about the higher order structure of these critical pure- lining or P segments. Serial cysteine mutagenesis reveals a pattern of side- chain accessibility that contradicts currently favored structural models based on α-helices or β-strands. Like the active sites of many enzymes of known structure, the sodium channel pore consists of irregular loop regions.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - Jan 9 1996|
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