Structure of the human CRFB4 gene: Comparison with its IFNAR neighbor

G. Lutfalla, M. G. McInnis, S. E. Antonarakis, G. Uzé

    Research output: Contribution to journalArticle

    Abstract

    The cytokine receptor family consists of a growing number of structurally and evolutionarily related transmembrane receptors. CRFB4 and IFNAR are two of the most similar members of this family. They are encoded by two neighboring genes on both human chromosome 21 and murine chromosome 16. The sequence of the human CRFB4 gene was determined from the first exon to the last intron. The nature of the repetitive sequences present in the introns was analyzed and compared with those present in the human IFNAR gene. This analysis leads to considerations of the antiquity of the duplication that gave rise to both genes from a common ancestor. A pseudogene for USF has been identified in the IFNAR gene and a new definition for the repetitive sequence MER37 is proposed. The polymorphism associated with two CA repeats present in the CRFB4 gene is described.

    Original languageEnglish (US)
    Pages (from-to)338-344
    Number of pages7
    JournalJournal of Molecular Evolution
    Volume41
    Issue number3
    DOIs
    StatePublished - 1995

    Fingerprint

    Genes
    gene
    repetitive sequences
    genes
    Nucleic Acid Repetitive Sequences
    Chromosomes
    Introns
    introns
    chromosome
    chromosomes
    Chromosomes, Human, Pair 16
    Chromosomes, Human, Pair 21
    Pseudogenes
    Cytokine Receptors
    pseudogenes
    Human Chromosomes
    common ancestry
    Polymorphism
    exons
    comparison

    Keywords

    • Anchored reference locus
    • Gene evolution
    • Genetic polymorphism
    • Interferon receptor
    • Repeated sequences

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Genetics
    • Molecular Biology
    • Biochemistry
    • Biochemistry, Genetics and Molecular Biology(all)
    • Genetics(clinical)
    • Agricultural and Biological Sciences(all)
    • Agricultural and Biological Sciences (miscellaneous)

    Cite this

    Lutfalla, G., McInnis, M. G., Antonarakis, S. E., & Uzé, G. (1995). Structure of the human CRFB4 gene: Comparison with its IFNAR neighbor. Journal of Molecular Evolution, 41(3), 338-344. https://doi.org/10.1007/BF00186545

    Structure of the human CRFB4 gene : Comparison with its IFNAR neighbor. / Lutfalla, G.; McInnis, M. G.; Antonarakis, S. E.; Uzé, G.

    In: Journal of Molecular Evolution, Vol. 41, No. 3, 1995, p. 338-344.

    Research output: Contribution to journalArticle

    Lutfalla, G, McInnis, MG, Antonarakis, SE & Uzé, G 1995, 'Structure of the human CRFB4 gene: Comparison with its IFNAR neighbor', Journal of Molecular Evolution, vol. 41, no. 3, pp. 338-344. https://doi.org/10.1007/BF00186545
    Lutfalla, G. ; McInnis, M. G. ; Antonarakis, S. E. ; Uzé, G. / Structure of the human CRFB4 gene : Comparison with its IFNAR neighbor. In: Journal of Molecular Evolution. 1995 ; Vol. 41, No. 3. pp. 338-344.
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